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Background: Mercury, an element with threats of severe toxic insult to humans and no biological function, has a surprisingly extensive record of human exposure. Regardless of hesitancies toward its harmfulness, it has been historically identified with an almost supernatural power to provide protection from evil and sickness, give good fortune, lend aid in athletic undertakings, or even allow one to achieve immortality. Mercury poisoning is an iatrogenic disease even today as people attempt to achieve these effects through volitional injections into their body by practitioners. Although an uncommon practice in the United States, awareness of patient presentation after volitional injections of elemental mercury is necessary for appropriate treatment of these patients. We aim to increase awareness of the cultural practice of subcutaneous injections of mercury, as it is uncommonly seen in the United States, to contribute a broader understanding to the patient's medical presentation and describe an approach and the impact of medical and surgical intervention.
Methods: In this report, we describe a rare case of elemental mercury poisoning secondary to volitional subcutaneous injection to the arm. Initial management of care through chelation therapy and monitoring of renal and serum mercury levels in addition to symptoms of systemic spread was overseen by an internal medicine physician and poison control. Surgical intervention via full-thickness excision of the visible mercury to the right arm followed by local flap and skin grafting reconstruction was performed.
Conclusions: Mercury poisoning from intentional subcutaneous administration is an uncommon patient presentation in the United States; however, knowledge of management of this rare condition is important for effective management of iatrogenic mercury toxicity.
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http://dx.doi.org/10.1097/SAP.0000000000003988 | DOI Listing |
Arq Neuropsiquiatr
September 2025
Universidade Federal do Pará, Instituto de Ciências Biológicas, Belém PR, Brazil.
Mercury intoxication poses a significant challenge and growing threat to public health, particularly in the Amazon region. Despite a known history of neurological damage, as evidenced by Japan's Minamata disease, mercury intoxication remains underdiagnosed in Brazil. This review underscores the need for increased clinical awareness among neurologists, as mercury exposure has been linked to over 250 neurological symptoms, including cognitive impairment, cerebellar ataxia, peripheral neuropathy, and psychiatric disturbances.
View Article and Find Full Text PDFHipertens Riesgo Vasc
August 2025
Division of Endocrinology and Diabetes, Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO, United States.
F1000Res
August 2025
Department of Biological Sciences, Afe Babalola University, Afe Babalola University, Ado-Ekiti, Ekiti, 360101, Nigeria.
Heavy metal contamination has gradually become a highly significant global issue due to its continual existence in the environment and bioaccumulation in the ecosystems, posing deleterious risks to human health. The major objectives of the review is to investigate the sources, pathways, and toxicological impacts of heavy metals such as cadmium, lead, mercury, and arsenic, elucidating their health consequences and plausible mitigation strategies. Furthermore, the review explores the dual origins of heavy metal contamination; natural geological processes and anthropogenic activities such as industrial emissions, mining, and agricultural practices.
View Article and Find Full Text PDFJ Hazard Mater
September 2025
State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:
Ultrasensitive monitoring of mercury(II) (Hg) in environmental and biological systems is highly desirable due to the fact that this heavy metal ion is a ubiquitous pollutant worldwide. Despite the existence of numerous readily-available techniques for Hg-detection, optical probe-based fluorescence tracking stands out, as this powerful tool can offer the distinct advantages of real-time, noninvasive and particularly in vivo monitoring. Herein, a novel hemicyanine-based fluorescent probe (namely HDS-Hg) with an enhanced turn-on near-infrared (NIR) sensing of fluorescence response upon binding with Hg (λ/λ = 700 nm/765 nm) was constructed, which featured a rapid response, low detection limit, wide pH-tolerance, high sensitivity and selectivity as well as favorable mitochondria-targeting ability.
View Article and Find Full Text PDFAnn Glob Health
August 2025
School of Public Health and Social Work, Florida International University, Miami, USA.
Mercury contamination remains a significant public health concern in the Amazon basin. This review synthesizes recent evidence on mercury exposure, health outcomes, and emerging co-exposures in the Amazon countries. Data were presented at the Annual Conference of Global Health in the Americas, organized by Florida International University in Cartagena, Colombia on September 15, 2023, at a virtual session of the Consortium of Universities for Global Health on November 29, 2023, and subsequently updated with further literature search.
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