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Class III malocclusions with anterior crossbites pose significant challenges in orthodontic treatment, especially in growing children. This case report details the early intervention of a 12-year-old patient presenting with a Class III malocclusion characterized by an anterior crossbite and mandibular prognathism. A chincup was employed to inhibit mandibular growth and encourage maxillary development. Consistent use of the chincup, with regular follow-ups and adjustments, led to significant improvements. The anterior crossbite was corrected, resulting in a Class I molar relationship and an improved facial profile. The maxillary arch perimeter increased, providing space for the eruption of canines and premolars. This case demonstrates that early intervention with a chincup can effectively manage Class III malocclusion with an anterior crossbite, highlighting the importance of timely orthodontic assessment and treatment to achieve stable, long-term results.
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http://dx.doi.org/10.7759/cureus.62473 | DOI Listing |
Eur J Pharm Biopharm
September 2025
RaDes GmbH, Schnackenburgallee 114, 22525 Hamburg, Germany. Electronic address:
Polysorbate 20 (PS20) is one of the most commonly used non-ionic surfactants in cosmetics, pharmaceuticals and food products. Considered as biocompatible and non-irritating, it is further valued for its solubilising and protein stabilising properties. PS20 is manufactured through a multi-stage reaction of sorbitol with various fatty acids and ethylene oxide, resulting in a complex mixture of components with different molecular weights and polarity.
View Article and Find Full Text PDFInt J Biol Macromol
September 2025
Department of Computational Biology, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, India; Infosys Centre for Artificial Intelligence, Indraprastha Institute of Information Technology Delhi (IIIT-Delhi), Okhla Phase III, New Delhi, 110020, In
Understanding the structural and functional diversity of toxin proteins is critical for elucidating macromolecular behavior, mechanistic variability, and structure-driven bioactivity. Traditional approaches have primarily focused on binary toxicity prediction, offering limited resolution into distinct modes of action of toxins. Here, we present MultiTox, an ensemble stacking framework for the classification of toxin proteins based on their molecular mode of action: neurotoxins, cytotoxins, hemotoxins, and enterotoxins.
View Article and Find Full Text PDFPLoS Pathog
September 2025
Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Bern, Switzerland.
The parasitic protozoan Trypanosoma brucei has a single mitochondrial nucleoid, anchored to the basal body of the flagellum via the tripartite attachment complex (TAC). The detergent-insoluble TAC is essential for mitochondrial genome segregation during cytokinesis. The TAC assembles de novo in a directed way from the probasal body towards the kDNA.
View Article and Find Full Text PDFEnviron Monit Assess
September 2025
Indira Gandhi Conservation Monitoring Centre, World Wide Fund-India, New Delhi, 110003, India.
Understanding the intricate relationship between land use/land cover (LULC) transformations and land surface temperature (LST) is critical for sustainable urban planning. This study investigates the spatiotemporal dynamics of LULC and LST across Delhi, India, using thermal data from Landsat 7 (2001), Landsat 5 (2011) and Landsat 8 (2021) resampled to 30-m spatial resolution, during the peak summer month of May. The study aims to target three significant aspects: (i) to analyse and present LULC-LST dynamics across Delhi, (ii) to evaluate the implications of LST effects at the district level and (iii) to predict seasonal LST trends in 2041 for North Delhi district using the seasonal auto-regressive integrated moving average (SARIMA) time series model.
View Article and Find Full Text PDFEgypt Heart J
September 2025
Department of Cardiology, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, King Abdullah International Medical Research Center, Jeddah, Saudi Arabia.
Background: Long-term outcomes of transcatheter mitral valve edge-to-edge repair (TEER) are compared with medical therapy remain under investigation. This study evaluated the 3-year effects of MitraClip on mitral regurgitation (MR) severity, ventricular remodeling, and clinical outcomes in high surgical-risk patients.
Methods: A single-center retrospective cohort included 31 MitraClip patients (2016-2023) and 30 contemporaneous controls on maximally tolerated guideline-directed medical therapy.