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Confined masonry (CM) construction is being increasingly adopted for its cost-effectiveness and simplicity, particularly in seismic zones. Despite its known benefits, limited research exists on how the stiffness of confining elements influences the in-plane behavior of CM. This study conducted a comprehensive parametric analysis using experimentally validated numerical models of single-wythe, squat CM wall panels under quasi-static reverse cyclic loading. Various cross-sections and reinforcement ratios were examined to assess the impact of the confining element stiffness on the deformation response, the cracking mechanism, and the hysteretic behavior. The key findings included the observation of symmetrical hysteresis in experimental CM panels under cyclic loading, with a peak lateral strength of 114.3 kN and 108.5 kN in push-and-pull load cycles against 1.7% and 1.3% drift indexes, respectively. A finite element (FE) model was developed based on a simplified micro-modeling approach, demonstrating a maximum discrepancy of 2.6% in the peak lateral load strength and 5.4% in the initial stiffness compared to the experimental results. The parametric study revealed significant improvements in the initial stiffness and seismic strength with increased depth and reinforcement in the confining elements. For instance, a 35% increase in the lateral strength was observed when the depth of the confining columns was augmented from 150 mm to 300 mm. Similarly, increasing the steel reinforcement percentage from 0.17% to 0.78% resulted in a 16.5% enhancement in the seismic strength. These findings highlight the critical role of the stiffness of confining elements in enhancing the seismic performance of CM walls. This study provides valuable design insights for optimizing CM construction in seismic-prone areas, particularly regarding the effects of confining element dimensions and reinforcement ratios on the structural resilience.
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http://dx.doi.org/10.3390/ma17133100 | DOI Listing |
Rev Sci Instrum
September 2025
Department of Earth Sciences, University College London, London, United Kingdom.
We have developed a new true triaxial apparatus for rock deformation, featuring six servo-controlled loading rams capable of applying maximum stresses of 220 MPa along the two horizontal axes and 400 MPa along the vertical axis to cubic rock samples of 50 mm side. Samples are introduced into a steel vessel, allowing rock specimens to be subjected to confining pressures of up to 60 MPa. Pore fluid lines connected to two pump intensifiers enable high-precision permeability measurements along all three principal stress directions.
View Article and Find Full Text PDFToxicon
September 2025
Research and Innovation Hub, Innovation Aesthetics, London UK.
Botulinum Neurotoxin Type A (BoNT-A) remains the cornerstone of glabellar frown line treatment, yet conventional low-dose, high-volume protocols often result in limited durability and imprecise diffusion. This study presents multiscale, in silico framework specifically designed to evaluate high-dose (60-80 Units), low-volume (≤0.045 mL/site) BoNT-A glabellar injection strategies across anatomically realistic conditions.
View Article and Find Full Text PDFMol Phylogenet Evol
August 2025
Pós-graduação em Biodiversidade e Evolução (PPGBE), Museu Paraense Emílio Goeldi, Caixa Postal 399, CEP 66040-170 Belém, Pará, Brazil; Instituto Tecnológico Vale - Desenvolvimento Sustentável, Belém, Pará, Brazil. Electronic address:
Warbling antbirds consist of an avian genus (Hypocnemis) with a wide distribution, confined to the Amazon basin, and whose true diversity and evolutionary history remain poorly understood. Here, we used sequences of 2,222 Ultra-conserved Elements (UCEs) and 30 exons loci from 58 specimens belonging to all currently recognized Hypocnemis species and all but one subspecies to infer phylogenies, population structure, interspecific limits, and the genus' biogeographic history. A consensus of phylogenies, networks, and phylogeographic structure analyses recovered up to thirteen independent evolutionary units within the genus, which currently has eight named species.
View Article and Find Full Text PDFbioRxiv
August 2025
Department and School of Medicine, University of California San Diego, La Jolla, CA 92093.
Enhancers serve as the major genomic elements regulating mammalian signal-dependent transcriptional programs, characterized by alternating periods of target gene "bursting" and "non-busting" that require investigation of induced enhancer condensates and locus motility in real time to provide dynamic insights into signal/ligand-dependent regulatory events. Here, endogenous live cell imaging has revealed the altered chromosomal dynamics/condensate formation occurring during estrogen receptor α (ERα)-dependent target gene bursting/post-bursting and chronic activation events. Simultaneous DNA/RNA endogenous live imaging reveals that an increased mobility of acutely ERα-stimulated loci observed during the bursting phase is, unexpectedly, further increased in the subsequent non-burst phase.
View Article and Find Full Text PDFActa Biomater
September 2025
Arts et Métiers Institute of Technology, EPF Engineering School, Université Sorbonne Paris Nord, IBHGC-Institut de Biomécanique Humaine Georges Charpak, Paris, France.
The passive material properties of skeletal muscle are key to proper force transmission, and changes to muscle microstructure can have deleterious effects on whole tissue function. However, to the best of the authors' knowledge, it is not currently possible to predict the passive material properties of skeletal muscle with microstructural measurements such as titin isoform type and/or extracellular matrix collagen content, type, or organization. The goals of this work were to 1) develop an experimental dataset at the tissue length scale of passive skeletal muscle under multiaxial loading conditions, 2) develop a biphasic microstructural model of skeletal muscle, and 3) calibrate, validate, and implement such a model.
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