Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

A subtype of cutaneous lupus erythematosus known as lupus erythematosus tumidus (LET) is characterized by sun-exposed areas that typically display urticaria-like papules and plaques. For LET, systemic therapy with antimalarials - particularly hydroxychloroquine (HCQ) - is the first line of treatment. Even though the safety profile of these medications appears to be high, there have been very few reports of side effects in the literature, including hemolytic anemia, retinal toxicity, maculopapular rash, gastrointestinal disturbance, and blue-gray discoloration of the skin or mucous membranes. Here, we report a unique instance of a 46-year-old LET smoker who, following HCQ treatment, developed a generalized myopathy.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11228567PMC
http://dx.doi.org/10.4081/dr.2023.9771DOI Listing

Publication Analysis

Top Keywords

generalized myopathy
8
lupus erythematosus
8
hcq treatment
8
hydroxychloroquine-induced generalized
4
myopathy patient
4
patient lupus
4
lupus tumidus
4
tumidus case
4
case report
4
report subtype
4

Similar Publications

Polymyalgia rheumatica (PMR) is a prevalent chronic inflammatory disorder among the elderly, presenting diagnostic and therapeutic challenges. Existing treatments like glucocorticoids have significant side effects, and the molecular mechanisms of PMR remain unclear. This study employed a 2-sample bidirectional Mendelian randomization approach to explore the causal relationship between 1091 metabolites, 309 metabolite ratios, and PMR risk.

View Article and Find Full Text PDF

Background: Psoriatic arthritis (PsA) affects joints and entheses. The objective is to use ultrasound (US) to see inflammatory changes in joints and entheses in patients with active PsA starting Apremilast.

Primary Objective: 20% reduction in the US index (UIC) at 12 months.

View Article and Find Full Text PDF

Monoclonal gammopathy-associated myopathies (MGAMs) are rare yet treatable myopathies that occur in association with monoclonal gammopathies. These myopathies include light chain (AL) amyloidosis myopathy, sporadic late-onset nemaline myopathy (SLONM), scleromyxedema with associated myopathy, and newly reported monoclonal gammopathy-associated glycogen storage myopathy (MGGSM), including the vacuolar myopathy with monoclonal gammopathy and stiffness. All these 4 distinct subtypes of MGAMs typically present in patients aged 40 or older, frequently with a subacute onset of rapidly progressive proximal and axial muscle weakness.

View Article and Find Full Text PDF

Background: Cardiac amyloidosis (CA) is characterized by atrial myopathy, which predisposes patients to atrial fibrillation (AF) and other atrial arrhythmias (AA). Although catheter ablation of AA is effective in the general population, its efficacy and safety in patients with CA remain unclear.

Objective: The study aimed to evaluate outcomes in patients with CA undergoing catheter ablation for typical atrial flutter (TAFL) and left atrial (LA) arrhythmias and to assess the presence and influence of LA low-voltage areas (LVA) in the latter.

View Article and Find Full Text PDF

Immune-mediated necrotizing myopathy: an emerging disorder.

Neurologia (Engl Ed)

September 2025

Unidad de ELA-Neuromuscular, Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain; IiSGM, Instituto de Investigación Sanitaria Gregorio Marañón.

Objectives: To describe the main features and the clinical management of a cohort of patients with immune-mediated necrotizing myopathy (IMNM).

Methods: We conducted an observational, monocentric, retrospective study of IMNM patients diagnosed in the Neuromuscular Unit of a tertiary hospital in Madrid (Spain) between 2013 and 2021.

Results: Sixteen IMNM cases were diagnosed, with a median age of 71.

View Article and Find Full Text PDF