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Background: Exposure to heat and cold poses a serious threat to human health. In the UK, hotter summers, milder winters and an ageing population will shift how populations experience temperature-related health burdens. Estimating future burdens can provide insights on the drivers of temperature-related health effects and removing biases in temperature projections is an essential step to generating these estimates, however, the impact of various methods of correction is not well examined.
Methods: We conducted a detailed health impact assessment by estimating mortality attributable to temperature at a baseline period (2007-2018) and in future decades (2030s, 2050s and 2070s). Epidemiological exposure-response relationships were derived for all England regions and UK countries, to quantify cold and heat risk, and temperature thresholds where mortality increases. UK climate projections 2018 (UKCP18)were bias-corrected using three techniques: correcting for mean bias (shift or SH), variability (bias-correction or BC) and extreme values (quantile mapping or QM). These were applied in the health impact assessment, alongside consideration of population ageing and growth to estimate future temperature-related mortality.
Findings: In the absence of adaptation and assuming a high-end emissions scenario (RCP8.5), annual UK temperature-related mortality is projected to increase, with substantial differences in raw vs. calibrated projections for heat-related mortality, but smaller differences for cold-related mortality. The BC approach gave an estimated 29 deaths per 100,000 in the 2070s, compared with 50 per 100,000 using uncorrected future temperatures. We also found population ageing may exert a bigger impact on future mortality totals than the impact from future increases in temperature alone. Estimating future health burdens associated with heat and cold is an important step towards equipping decision-makers to deliver suitable care to the changing population. Correcting inherent biases in temperature projections can improve the accuracy of projected health burdens to support health protection measures and long-term resilience planning.
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http://dx.doi.org/10.1016/j.envres.2024.119565 | DOI Listing |
J Med Internet Res
September 2025
Centre Hospitalier Rives de Seine, Courbevoie, France.
Background: Every year in France, 40% of people aged ≥80 years are hospitalized, with an average length of hospital stay of 25 days and a readmission rate of 14% to 30% within the month following discharge. This situation is putting pressure on the health care system, encouraging the reinforcement of home care to reduce avoidable hospitalization. The EPOCA remote patient monitoring (RPM) system is a medical and social telehealth solution specialized in RPM, teleconsultation, tele-expertise, and care coordination in emergency medicine and geriatrics.
View Article and Find Full Text PDFNeurology
October 2025
Department of Radiology, Mayo Clinic, Rochester, MN.
Background And Objectives: The relationship between insomnia and cognitive decline is poorly understood. We investigated associations between chronic insomnia, longitudinal cognitive outcomes, and brain health in older adults.
Methods: From the population-based Mayo Clinic Study of Aging, we identified cognitively unimpaired older adults with or without a diagnosis of chronic insomnia who underwent annual neuropsychological assessments (z-scored global cognitive scores and cognitive status) and had quantified serial imaging outcomes (amyloid-PET burden [centiloid] and white matter hyperintensities from MRI [WMH, % of intracranial volume]).
Cien Saude Colet
August 2025
Faculdade Ciências Médicas de Minas Gerais. Alameda Ezequiel Dias 275, Centro. 30130-110 Belo Horizonte MG Brasil.
The aim is to identify the prevalence and main factors associated with self-reported poor sleep quality in Brazilian adults aged 50 and older. A cross-sectional study with participants from the Brazilian Longitudinal Study of Aging (2019-2021). A total of 9,849 participants aged 50 and older with complete information for the variables of interest were included.
View Article and Find Full Text PDFCien Saude Colet
August 2025
Departamento de Ciências Farmacêuticas, Universidade Federal de São Paulo. São Paulo SP Brasil.
The scope of this study was to conduct an analysis on the effect of the Age-Period-Cohort (APC) on ovarian cancer mortality in the South and Northeast regions of Brazil. The APC models were estimated by Poisson regression through estimable functions in women aged 30 and over residing in the states of the South and Northeast regions. Upon estimating the APC models, a positive gradient was found in mortality rates with advancing age in all locations The South region showed a reduction in the risk of death in the last two periods (RR2010-2014 0.
View Article and Find Full Text PDFJ Clin Endocrinol Metab
September 2025
Department of Endocrinology, Ghent University Hospital; Department of Internal Medicine & Pediatrics, Ghent University, Corneel Heymanslaan 10, 9000 Ghent, Belgium.
Context: Direct measurement of serum free testosterone (FT) may help evaluate hypogonadism in men. However, up to present, availability of reference ranges for measured FT (mFT) is limited.
Objective: To establish age-stratified reference ranges for mFT in healthy and community-dwelling adult men.