Monkey see, monkey do: Tracking iPS-cardiomyocyte survival and maturation in autografts.

Cell Stem Cell

Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong 518107, China; Advanced Medical Technology Center, Zhongshan School of Medicine and the First Affiliated Hospital, Sun Yat-Sen University, Guangdong 510080, China; NHC Key Laboratory of Assisted Circu

Published: July 2024


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Article Abstract

Induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) therapy has emerged as a highly promising field of heart repair. Lin et al. presented compelling evidence on the long-term engraftment and maturation of autologous iPSC-CMs in two rhesus macaques, demonstrating unprecedented cardiac autografting data in large animal models without the need of immunosuppressants.

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http://dx.doi.org/10.1016/j.stem.2024.06.006DOI Listing

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