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DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease. | LitMetric
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DRD4 gene polymorphism and impulse control disorder induced by dopamine agonists in Parkinson's disease.

Viviana Torres , Jesica Pérez-Montesino , Rubén Fernández-Santiago , Manel Fernández , Ana Camara , Yaroslau Compta , María-José Martí , Àlex Guerra Beltran , José Rios , Francesc Valldeoriola , Mario Ezquerra

Ann Clin Transl Neurol

Lab of Parkinson's disease and other Neurodegenerative Movement Disorders: Clinical and Experimental Research, Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, 08036, Catalonia, Spain.

Published: August 2024

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Article Abstract

Impulse control disorders and their consequences display variability among individuals, indicating potential involvement of environmental and genetic factors. In this retrospective study, we analyzed a cohort of Parkinson's disease patients treated with dopamine agonists and investigated the influence of the dopamine D4 receptor gene polymorphism, DRD4 7R+, which is linked to psychiatric disorders, impulsive traits, and addictive behaviors. We found that DRD4 7R+ is a significant genetic risk factor associated with the severity of ICD.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330210PMC
http://dx.doi.org/10.1002/acn3.52111DOI Listing

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