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Article Abstract
Background: Currently, the species are responsible for a variety of serious infections and are already considered a global public health problem, especially in underdeveloped countries, where surveillance and monitoring programs are still scarce and limited. Analyses were performed on the complete genome of an extensively antibiotic-resistant strain of , which was isolated from a patient with non-Hodgkin's lymphoma, who had been admitted to a hospital in the city of Manaus, Brazil.
Methods: Phenotypical identification and susceptibility tests were performed in automated equipment. Total DNA extraction was performed using the PureLink genomic DNA mini-Kit. The genomic DNA library was prepared with Illumina Microbial Amplicon Prep and sequenced in the MiSeq Illumina Platform. The assembly of the whole-genome and individual analyses of specific resistance genes extracted were carried out using online tools and the Geneious Prime software.
Results: The analyses identified an extensively resistant ST90 clone of carrying different genes, including , , , , and , [], [, (qnrB1)], , and , , , and B, in addition to resistance to chlorhexidine, which is widely used in patient antisepsis.
Conclusions: These findings highlight the need for actions to control and monitor these pathogens in the hospital environment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202416 | PMC |
| http://dx.doi.org/10.3390/genes15060814 | DOI Listing |
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