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http://dx.doi.org/10.1007/s00590-024-04025-2 | DOI Listing |
Cell Rep Methods
August 2025
Department of Biomedical Engineering and Computational Biology Program, OHSU, Portland, OR, USA; Knight Cancer Institute, OHSU, Portland, OR, USA. Electronic address:
We present UniFORM, a non-parametric, Python-based pipeline for normalizing multiplex tissue imaging (MTI) data at both the feature and pixel levels. UniFORM employs an automated rigid landmark registration method tailored to the distributional characteristics of MTI, with UniFORM operating without prior distributional assumptions and handling both unimodal and bimodal patterns. By aligning the biologically invariant negative populations, UniFORM removes technical variation while preserving tissue-specific expression patterns in positive populations.
View Article and Find Full Text PDFJ Med Imaging (Bellingham)
September 2025
Otto von Guericke University, Institute for Medical Engineering and Research Campus STIMULATE, Magdeburg, Germany.
Purpose: The combination of multi-layer flat panel detector (FPDT) X-ray imaging and physics-based material decomposition algorithms allows for the removal of anatomical structures. However, the reliability of these algorithms may be compromised by unaccounted materials or scattered radiation.
Approach: We investigated the two-material decomposition performance of a multi-layer FPDT in the context of 2D chest radiography without and with a 13:1 anti-scatter grid employed.
J Healthc Leadersh
August 2025
Department of Medical Equipment Technology, College of Applied Medical Science, Majmaah University, Majmaah, 11952, Saudi Arabia.
Introduction: Clinical Engineering Departments (CEDs) face growing challenges in managing rapidly evolving medical technologies and increasing equipment inventories under constrained budgets and limited human resources. These pressures often result in strained staffing capacity and imbalanced workload distribution. This study aimed to develop and validate a metrics-driven hybrid staffing model to optimize workforce allocation and improve workload efficiency across National Guard Health Affairs (NGHA) hospitals in Saudi Arabia.
View Article and Find Full Text PDFIEEE Trans Radiat Plasma Med Sci
May 2025
Department of Nuclear, Plasma and Radiological Engineering, and the Department of Bioengineering and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Champaign, IL 61801 USA.
This study introduces a novel maximum-likelihood-based data preconditioning method for a 3-D position sensitive cadmium zinc telluride (CZT) detector used in the dynamic extremity-single photon emission computed tomography imaging system, an organ-dedicated Single-Photon Emission computed tomography system optimized for imaging peripheral vascular diseases in lower extremities. The 3-D CZT detectors offer subpixel resolution of ~0.5 mm FWHM in directions and an ultrahigh energy resolution of 3 keV at 200 keV, 4.
View Article and Find Full Text PDFMach Learn Med Imaging
October 2024
Martinos Center for Biomedical Imaging, MGH & Harvard Medical School.
Parcellation of mesh models for cortical analysis is a central problem in neuroimaging. Most classical and deep learning methods have requisites in terms of mesh topology, requiring inputs that are homeomorphic to a sphere (i.e.
View Article and Find Full Text PDF