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Various industrial processes require motion profiles that determine machine movement over time for workpiece transfer, with the goal of minimizing transfer time to enhance productivity. However, pursuing the maximum speed can trigger excessive motion-induced vibration, which can reduce the manufacturing efficiency, accuracy and operational lifespan of the system. This study proposes a generalized motion profile optimization method that considers the strategic placement of inherent zeros within the motion profile: each inherent zero contributes to the reduction of residual vibration or optimization of arrival time. By offering freedom to the placement of zeros, four optimization options for polynomial-based motion profiles of each order are proposed, expanding on existing work that offered a single option. All proposed optimization options have closed-form solutions, making them easily applicable to industrial applications. The practical applicability of the suggested methodology is demonstrated through case studies and experiments.
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http://dx.doi.org/10.1016/j.isatra.2024.06.013 | DOI Listing |
Magn Reson Chem
September 2025
Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan.
We reveal contrasting behaviors in molecular motion between the two materials, including the identification of resonance-enhanced dynamic features in elastomers. We present a depth-resolved analysis of molecular dynamics in semicrystalline polytetrafluoroethylene (PTFE) and fully amorphous fluorinated elastomer (SIFEL) films using static-gradient solid-state F NMR imaging. By measuring spin-lattice relaxation rates ( ) at multiple frequencies and evaluating the corresponding spectral density functions, we reveal distinct dynamic behaviors between the two materials.
View Article and Find Full Text PDFEur J Pharmacol
September 2025
Departamento de Química and Institute for advanced research in chemical Science (IAdChem), Facultad de Ciencias, Módulo 13, Universidad Autónoma de Madrid, 28049 Madrid, Spain.
The Skp2-Cks1 protein-protein interaction (PPI) within the SCF ubiquitin ligase acts as a co-receptor for phosphorylated CDK inhibitors-most prominently p27-relieving CDK inhibition and advancing the cell cycle, a dependency accentuated in RB-pathway-defective cancers. Crystallographic and cryo-EM analyses delineate a composite pocket formed by the Skp2 leucine-rich-repeat groove and the phosphate-recognition site of Cks1; Cks1-centered open-closed motions further influence druggability. Using HTRF/TR-FRET and AlphaScreen biochemistry, alongside cell-based target-engagement readouts in some studies, three small-molecule classes have emerged that disrupt this PPI: 1,3-diphenyl-pyrazines and triazolo[1,5-a]pyrimidines (lead E35) with low-micromolar potency, and "Skp2E3LI" compounds with micromolar cellular activity.
View Article and Find Full Text PDFNeuroscience
September 2025
Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Suita, Osaka 565-0871, Japan. Electronic address:
Visual motion perception declines during natural aging in most animals including humans. Edible berries of blackcurrant (BC) and its extracted anthocyanins (BCAs) have beneficial effects on human eyes. However, the effect of BCAs on the perception of moving objects and other dynamic visual patterns remains unknown.
View Article and Find Full Text PDFMagn Reson Med
September 2025
School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai, China.
Purpose: To develop a rapid 2D free-running myocardial mapping technique that is robust to through-plane respiratory motion.
Methods: A free-running golden angle radial sequence consisting of encoding and self-navigated auto motion calibration (SNAC) was developed. The encoding adopted inversion recovery (IR) prepared interleaved multi-slice acquisition with optimized inter-slice gap to ensure a uniform excitation of the middle slice regardless of through-plane respiratory motion.
Magn Reson Med
September 2025
Department of Mechanical Science and Bioengineering, The University of Osaka Graduate School of Engineering Science, Osaka, Japan.
Purpose: Diffusion-weighted imaging (DWI) and intravoxel incoherent motion (IVIM) imaging are well-established approaches for evaluating cerebrospinal fluid (CSF) flow in subarachnoid and perivascular spaces, and have recently been applied to study ventricular CSF flow. However, DWI does not directly measure flow velocity, and the physical implications of DWI measurements are unclear. This study aimed to provide a theoretical interpretation of the DWI and IVIM imaging of CSF flow velocity fields.
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