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We present a new class of tunable aryl alkyl ionic liquids (TAAILs) based on 1-aryl-4,5-dimethylimidazolium cations with electron-withdrawing and -donating substituents in different positions of the phenyl ring and the bis(trifluoromethylsulfonyl)imide (NTf) anion. We investigated the effect of additional methyl groups in the backbone of the imidazolium core on the physical properties regarding viscosity, conductivity and electrochemical window. With an electrochemical window of up to 6.3 V, which is unprecedented for TAAILs with an NTf anion, this new class of TAAILs demonstrates the opportunities that arise from modifications in the backbone of the imidazolium cation.
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http://dx.doi.org/10.3762/bjoc.20.110 | DOI Listing |
Channels (Austin)
December 2025
Biorheology Research Laboratory, Faculty of Health, Griffith University, Gold Coast, Australia.
The hallmarks of mechanosensitive ion channels have been observed for half a century in various cell lines, although their mechanisms and molecular identities remained unknown until recently. Identification of the bona fide mammalian mechanosensory Piezo channels resulted in an explosion of research exploring the translation of mechanical cues into biochemical signals and dynamic cell morphology responses. One of the Piezo isoforms - Piezo1 - is integral in the erythrocyte (red blood cell; RBC) membrane.
View Article and Find Full Text PDFEpidemiol Serv Saude
September 2025
Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
Objectives: To assess the time taken to diagnose cervical cancer in Brazil and identify associated sociodemographic and clinical factors in the period 2016-2020.
Methods: This was a cross-sectional study of cervical neoplasms diagnosed between 2016 and 2020, using data collected from the Hospital Cancer Registry. The logistic regression model was applied to calculate odds ratios (OR) and 95% confidence intervals (95%CI).
Epidemiol Serv Saude
September 2025
Universidade Estadual do Norte do Paraná, Programa de Pós-Graduação em Enfermagem em Atenção Primária à Saúde Bandeirantes, PR, Brazil.
Objectives: To analyze the temporal trend and identify spatial clusters of breast cancer mortality in Paraná state between 2012 and 2021.
Methods: This was a time series study, with spatial analysis of breast cancer mortality rates in the 399 municipalities of Paraná. Data were selected from the Mortality Information System.
Epidemiol Serv Saude
September 2025
Universidade Federal de Minas Gerais, Departamento de Farmácia Social, Belo Horizonte, MG, Brazil.
Objectives: To assess the persistence and time until discontinuation of biological drugs used by people with ankylosing spondylitis treated in the Brazilian Unified Health System and to investigate the factors associated with them.
Methods: Data were collected from an open historical cohort between 2018 and 2023 on the administrative processes required for requesting medicines from the specialized component of pharmaceutical assistance in Minas Gerais, Brazil. Sociodemographic and clinical data and treatment history were collected.
J Bras Pneumol
September 2025
. Santa Casa de Misericórdia de Mogi Mirim, Mogi Mirim (SP) Brasil.
Objective: Respiratory syncytial virus (RSV) is a major cause of severe respiratory infections in older adults, particularly those with comorbidities. Despite its clinical impact, RSV remains underdiagnosed and underreported. We sought to assess the burden of RSV in older adults (≥ 60 years of age) in Brazil using national surveillance data for the 2022-2023 period.
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