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http://dx.doi.org/10.1152/ajpgi.00090.2024 | DOI Listing |
Am J Physiol Gastrointest Liver Physiol
August 2024
Tumor Microenvironment and Metastasis Section, The Hormel Institute, University of Minnesota, Austin, Minnesota, United States.
Am J Physiol Gastrointest Liver Physiol
May 2024
Department of Cancer Biology, Mayo Clinic, Jacksonville, Florida, United States.
Tissue-specific gene manipulations are widely used in genetically engineered mouse models. A single recombinase system, such as the one using Alb-Cre, has been commonly used for liver-specific genetic manipulations. However, most diseases are complex, involving multiple genetic changes and various cell types.
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