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Over the past decade, significant endeavors have been directed toward establishing an optimal oocyte number to maximize the chances for successful in vitro fertilization outcomes. The effectiveness of assisted reproductive technologies has greatly improved, and more good-quality embryos are being created in each cycle. However, many of these embryos remain unused. Notably, in Europe, approximately one-third of couples did not use their surplus cryopreserved embryos. Surplus embryos pose a challenge for patients and clinics. Embryo disposal practices are not the same all over the continent, with embryo donation and embryo discharge not allowed in several countries. In this scenario, limiting the number of surplus embryos by reducing the number of inseminated oocytes, according to couple clinical history, could be a strategy.
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http://dx.doi.org/10.1007/s10815-024-03159-w | DOI Listing |
Soc Sci Med
August 2025
Centre for Gender Research, Uppsala University, Sweden. Electronic address:
The use of donor eggs, sperm and embryos in medically assisted reproduction (MAR) provide new possibilities for reproductive assistance and family-making. In clinical practice, it also brings to light questions of responsibility and ethical conduct. Despite this, fertility practitioners' reasoning in clinical decision-making remains surprisingly understudied.
View Article and Find Full Text PDFLab Anim
August 2025
Institute for Biological and Chemical Systems-Biological Information Processing (IBCS-BIP), Karlsruhe Institute of Technology, Germany.
The use of zebrafish as an animal model for biomedical and toxicological research has increased dramatically over the past decade, alongside a growing need to adopt the 3Rs principles to ensure ethically acceptable animal experimentation. Currently, one of the main challenges concerns 'surplus' animals that are unavoidably generated as part of an experimental procedure and are unsuitable for experimental analysis because they do not have the desired genotype, are too old or have the wrong sex. However, justifying the sacrifice of animals for these reasons is morally debatable and current ethics legislation in some countries insists they should nevertheless be maintained and left to die of natural causes.
View Article and Find Full Text PDFHum Reprod
August 2025
IVIRMA Global Research Alliance, Genera, Clinica Valle Giulia, Rome, Italy.
Study Question: Can an artificial intelligence (AI)-based oocyte scoring system reliably predict the developmental competence of fresh donor oocytes?
Summary Answer: The AI-derived Magenta Score was significantly associated with fertilization, blastocyst formation, and helpful to estimate cumulative live birth rates, although a trend toward overestimation was observed in a subset of cycles.
What Is Known Already: Oocyte quality is a critical determinant of IVF success; however, standardized and objective methods for its assessment are lacking. Current allocation strategies in oocyte donation cycles often neglect recipient-related factors and risk overproduction of surplus embryos.
J Law Biosci
July 2025
International Center for Health, Law and Ethics, University of Haifa, Haifa, Israel.
Numerous cryopreserved surplus embryos are being stored in IVF units in Western countries. IVF patients are required to choose and consent to disposition options for their surplus embryos upon starting treatment. We focus on the option of embryo donation to others for reproductive purposes.
View Article and Find Full Text PDFF1000Res
August 2025
Molecular and Clinical Cancer Medicine, University of Liverpool Institute of Systems Molecular and Integrative Biology, Liverpool, England, UK.
Background: Pleural mesothelioma is a cancer of the lung lining associated with asbestos exposure. Platinum/pemetrexed chemotherapy has been used for many years but provides little benefit and, despite recent immunotherapy advances, prognosis remains poor underpinning the need for development of novel therapeutics or drug repurposing. Fertilized hens' eggs provide a rapid and cost-effective alternative to murine models of pleural mesothelioma which are commonly used in preclinical studies, with chorioallantoic membrane (CAM) xenografts being a partial replacement for mouse flank xenografts.
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