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Background: Most people who smoke cigarettes report they want to quit in the future, but only 20 % are ready to quit within the next 30 days. This 3-arm pilot randomized controlled trial examined the feasibility and initial efficacy of a novel smartphone-based intervention that aimed to induce smoking cessation attempts among adults not initially ready to quit.
Methods: Participants randomized into the two intervention groups (Group 1: Phoenix App Only; Group 2: Phoenix App + Nicotine Replacement Therapy) received daily smoking cessation messages via smartphone application that were tailored to their current readiness to quit, while the attention control group (i.e., Factoid) received messages not related to smoking cessation. All participants completed a weekly survey for 26 weeks and used the app to set quit dates when/if desired.
Results: Participants (N=152) were female (67.8 %), White (75.7 %), 50.0 years old (SD=12.5), and smoked 20.4 cigarettes per day (SD=10.5). Results indicated that the Phoenix interventions were feasible (e.g., participants viewed ~185 messages over 26 weeks; 74.8 % of weekly surveys were completed; 85.5 % completed the 26-week follow-up assessment). Phoenix participants set more quit dates, set quit dates sooner, were abstinent for more days, and used smoking cessation medications on more days than those assigned to the Factoid group.
Conclusions: This low-burden, smartphone-based smoking cessation induction intervention may increase smoking cessation attempts, and may reduce barriers that are encountered with traditional in-person or call-based interventions.
Trial Registration: Clinicaltrials.gov number: NCT03405129; https://clinicaltrials.gov/ct2/show/NCT03405129.
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http://dx.doi.org/10.1016/j.drugalcdep.2024.111351 | DOI Listing |
Future Sci OA
December 2025
Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.
Background: Smoking induces inflammation in the heart and intima layer of blood vessels by activating nuclear factor kappa B, which controls the transcription of immunoglobulin free light chain (FLC)-κ. FLC levels are indicative of higher mortality in the overall population and poorer prognoses in cardiovascular diseases. This study aimed to analyze the effect of smoking cessation (SC) on the levels of FLCs and markers of inflammation and heart failure.
View Article and Find Full Text PDFTob Control
September 2025
Medical Practice Evaluation Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Background: As part of its COVID-19 response, South Africa banned tobacco sales between March and August 2020. We examined self-reported tobacco use before, during and after the ban among a rural South African population with high HIV prevalence.
Methods: Between May 2021 and November 2022, we conducted a telephonic survey on tobacco use among a purposively selected subset of a population-based cohort in rural KwaZulu-Natal.
J Vasc Surg
September 2025
Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, Yale School of Medicine, New Haven, CT.
Introduction: Although smoking cessation has been shown to improve outcomes after lower extremity revascularization (LER), the impact of cessation duration has not been well defined. This study investigates the impact of two cessation durations on LER outcomes in patients with chronic limb-threatening ischemia (CLTI).
Methods: The Peripheral Vascular Intervention, Infrainguinal Bypass, and Suprainguinal Bypass modules of the Vascular Quality Initiative (VQI) were utilized to identify patients whose first recorded LER occurred between 2016-2024 for CLTI.
J Affect Disord
September 2025
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, 1845 N. Soto St., Los Angeles, CA, 90032, USA; Department of Psychology, University of Southern California, 3620 McClintock Ave., Los Angeles, CA, 90089, USA.
Introduction: Individuals with elevated depression symptoms experience low positive affect, high negative affect, and cognitive dysfunction. Affective and cognitive disruptions also occur during cigarette abstinence. This study examined whether depression symptom levels associate with affect and cognitive dysfunction during a cigarette quit attempt.
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