Article Synopsis
- Alcohols are common chemical feedstocks but are not often used as partners in metal-catalyzed reactions.
- A new method using copper and photoredox catalysis allows for the conversion of alcohols into valuable C-N bonds by coupling with nucleophiles.
- This approach successfully works with various alcohols and 18 different types of nucleophiles, offering a more efficient way to create pharmaceutical compounds.
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Article Abstract
Alcohols are among the most abundant chemical feedstocks, yet they remain vastly underutilized as coupling partners in transition metal catalysis. Herein, we describe a copper metallaphotoredox manifold for the open shell deoxygenative coupling of alcohols with -nucleophiles to forge C()-N bonds, a linkage of high value in pharmaceutical agents that is challenging to access via conventional cross-coupling techniques. -heterocyclic carbene (NHC)-mediated conversion of alcohols into the corresponding alkyl radicals followed by copper-catalyzed C-N coupling renders this platform successful for a broad range of structurally unbiased alcohols and 18 classes of -nucleophiles.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11610502 | PMC |
| http://dx.doi.org/10.1021/jacs.4c04477 | DOI Listing |
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