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http://dx.doi.org/10.1016/j.cmet.2024.05.004 | DOI Listing |
Physiol Rep
September 2025
Military Nutrition Division, U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA.
This study investigated the effects of fermentable fiber and polyphenol supplementation on mood and cognition following rapid ascent to simulated 4300 m. Healthy adults (n = 13, 21 ± 3 years) participated in a randomized, placebo-controlled crossover study consisting of three, 2-week phases separated by ≥1 week. Food products containing the fiber and polyphenol supplement or placebo were consumed during each phase.
View Article and Find Full Text PDFBiomed Pharmacother
September 2025
Laboratory of Veterinary Physiology, Cooperative Department of Veterinary Medicine, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan. Electronic address:
Early life stress due to maternal separation (MS) disrupts the gut-brain axis (GBA), leading to long-term neurobiological and behavioral deficits, particularly social behavior impairments. Although various probiotics have shown therapeutic potential, the efficacy of heat-killed Enterococcus faecalis EC-12 (EC-12) as a para-probiotic remains largely unknown. This study aimed to evaluate the therapeutic potential of EC-12 in reversing MS-induced behavioral and molecular abnormalities in mice.
View Article and Find Full Text PDFJ Neurochem
September 2025
Visceral Pain Research Group, Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia.
The distal colon and rectum (colorectum) are innervated by two distinct spinal (splanchnic and pelvic) afferent nerve pathways. This study aimed to identify where the sensory information relayed by splanchnic and pelvic afferents integrates within the brainstem. Microinjection of transneuronal viral tracer (herpes simplex virus-1 H129 strain expressing EGFP, H129-EGFP) into the distal colon was used to assess the brainstem structures receiving ascending input from the colorectum.
View Article and Find Full Text PDFmBio
August 2025
Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, Wisconsin, USA.
There is a wealth of signals present in the human gut that mediate host-microbiota communication and intersect with the gut-brain-axis. There is differential spatial localization of the tryptophan derivatives serotonin and indole in the gut, which are important cues for enteric pathogens to find their colonization niche. Both signals are sensed by enteric pathogens such as enterohemorrhagic (EHEC) and , a murine pathogen extensively employed as a surrogate animal model for EHEC.
View Article and Find Full Text PDFNeuropharmacology
November 2025
Florey Institute of Neuroscience and Mental Health, Melbourne Brain Centre, University of Melbourne, Parkville, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Parkville, Australia. Electronic address:
Psilocybin, a serotonergic compound that produces psychedelic effects primarily through activation of the 5-HT receptor, has shown promise in treating neuropsychiatric conditions, including obsessive-compulsive disorder (OCD). However, the effects of chronic psilocybin administration on gut function, microbiota, and behavioural phenotypes remain understudied. The present study investigated the effects of chronic psilocybin (0.
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