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http://dx.doi.org/10.1055/a-2311-5679 | DOI Listing |
Toxicol Mech Methods
September 2025
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Fluoropyrimidines are a class of chemotherapy drugs used to treat various solid tumors. 5-Fluorouracil (5-FU) an antimetabolite in the fluoropyrimidine family, which has shown remarkable efficacy against a variety of solid tumors, is a crucial medication in the treatment of cancer. However, severe organ toxicities frequently restrict its therapeutic potential.
View Article and Find Full Text PDFJ Morphol
September 2025
Retired, London, UK.
In live specimens of the nemertodermatidan Flagellophora apelti Faubel and Dörjes, 1978, a peculiar organ looking like a fascicle of bristles-and so called a broom organ by its discoverer-occupies the front third or so of the body. The animal can extrude the organ to splay the bristles in a fan-like array, each bristle having an adhesive tip. Described first by light histology as a bundle of flagella, this organ can be seen by transmission electron microscopy to be actually a bundle of exceedingly long necks of glands.
View Article and Find Full Text PDFPLoS One
September 2025
Instituto Cavanilles de Biodiversidad y Biología Evolutiva, Universidad de Valencia, Valencia, Spain.
The genitalia of Lepidoptera are complex structures that evolve rapidly and divergently. The endophallus of many lepidopterans is ornamented with elaborate sclerotized structures known as cornuti. In some species, the cornuti are deciduous and remain within the female genital tract after copulation; the function of these structures is virtually unknown.
View Article and Find Full Text PDFCephalalgia
September 2025
Instituto de Psiquiatria, HCFMUSP, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
IntroductionTypical migraine aura is characterized by transient focal neurologic symptoms, visual, sensory, dysphasic or other higher cortical dysfunctions. Their manifestations are multi-faceted, with inter and intra-variability.ObjectiveTo provide a narrative review describing contributions that assist in achieving a precise phenotypic classification of migraine aura.
View Article and Find Full Text PDFSci Rep
August 2025
Division of Anatomy, Center for Anatomy and Cell Biology, Medical University Vienna, 1090, Vienna, Austria.
The left sided segments of the prenatal liver receive blood enriched with oxygen and nutrients, while the right ones receive blood with low levels of oxygen and nutrients. We aimed at testing whether this affects the postnatal transcriptome of cells populating different liver segments and to explore the suitability of body donor material for transcriptomic analysis. 72 biopsies were harvested from 6 liver segments (LS) of 4 human body donors within the first 10 h post-mortem.
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