Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Spinal serotonin enables neuro-motor recovery (i.e., plasticity) in patients with debilitating paralysis. While there exists time of day fluctuations in serotonin-dependent spinal plasticity, it is unknown, in humans, whether this is due to dynamic changes in spinal serotonin levels or downstream signaling processes. The primary objective of this study was to determine if time of day variations in spinal serotonin levels exists in humans. To assess this, intrathecal drains were placed in seven adults with cerebrospinal fluid (CSF) collected at diurnal (05:00 to 07:00) and nocturnal (17:00 to 19:00) intervals. High performance liquid chromatography with mass spectrometry was used to quantify CSF serotonin levels with comparisons being made using univariate analysis. From the 7 adult patients, 21 distinct CSF samples were collected: 9 during the diurnal interval and 12 during nocturnal. Diurnal CSF samples demonstrated an average serotonin level of 216.6 67.7 nM. Nocturnal CSF samples demonstrated an average serotonin level of 206.7 75.8 nM. There was no significant difference between diurnal and nocturnal CSF serotonin levels (p = .762). Within this small cohort of spine healthy adults, there were no differences in diurnal versus nocturnal spinal serotonin levels. These observations exclude spinal serotonin levels as the etiology for time of day fluctuations in serotonin-dependent spinal plasticity expression.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/syn.22291 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Peri- and Postnatal High Fat Feeding Have Differential Effects on Executive Function and Associated Neurobiology in Aged Male and Female Mice.
Aging Cell
September 2025
Division of Biomedical and Life Sciences, Lancaster University, Lancaster, UK.
Almost half of pregnant women globally are currently estimated to be overweight or obese. Rates of childhood obesity are also on the rise, in part because of increased consumption of dietary saturated fats. However, the long-term effect of peri- and postnatal high fat (HF) feeding on cognitive function and neuronal expression has not yet been investigated.
View Article and Find Full Text PDFMonoamine depletion and oxidative imbalance underlie ketamine-induced motor deficits in adolescent rats.
Neurotoxicology
September 2025
Laboratory of Pharmacology of Inflammation and Behavioral (LAFICO), Health Science Institute, Federal University of Pará, Belém 66075110, PA, Brazil. Electronic address:
Ketamine has been widely used as a recreational substance by adolescents and young adults in nightclubs and raves in an acute manner, especially during the weekend. Considering the scarcity of evidence on the harmful consequences of adolescent ketamine recreational use on the central nervous system, primarily related to motor function, this study aimed to investigate the behavioral, biochemical, and neurochemical consequences on motor function induced by ketamine use, evaluating the motor cortex, cerebellum, and striatum in early abstinence. Adolescent female Wistar rats (28 days old) received ketamine by intranasal route (10mg/kg/day) for 3 consecutive days.
View Article and Find Full Text PDFDoes unfairness evoke anger or disgust? A quantitative neurofunctional dissection based on 25 years of neuroimaging.
Neurosci Biobehav Rev
September 2025
State Key Laboratory for Brain and Cognitive Sciences, The University of Hong Kong, 999077 Hong Kong, China; Department of Psychology, The University of Hong Kong, 999077 Hong Kong, China. Electronic address:
Over the last decades, the traditional 'Homo economicus' model has been increasingly challenged by converging evidence highlighting the critical impact of emotions on decision-making. A classic example is the perception of unfairness in the Ultimatum Game, where humans willingly sacrifice personal gains to punish fairness norm violators. While emotional mechanisms underlying such costly punishment are widely acknowledged, the distinct contributions of moral emotions, particularly anger and disgust, remain debated, partly due to methodological limitations in conventional experiments.
View Article and Find Full Text PDFInhibition of Indoleamine 2,3-dioxygenase by 1-Methyl-D-tryptophan (1-MT) rescued PTSD-like symptoms via downregulation of neuroinflammation and NMDA receptor.
Eur J Pharmacol
September 2025
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli; Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli. Electronic address: ashok.datusal
Post-traumatic stress disorder (PTSD) is a debilitating mental health condition stemming from exposure to traumatic events. Current treatment for PTSD is limited to the selective serotonin reuptake inhibitors, which are often associated with severe side effects and result in poor treatment adherence and limited effectiveness. Recent studies indicate that indoleamine 2,3-dioxygenase (IDO) may play a significant role in the development of stress-related disorders.
View Article and Find Full Text PDFSynergistic stress-relieving and cognitive-enhancing effects of walnut peptide and theanine in human brain organoid and mouse stress models.
Phytomedicine
August 2025
Laboratory of Neurological Disease Modeling and Translational Research, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address:
Background: Stress is a prevalent mental health concern that often emerges in late adolescence or early adulthood. Since 2007, the Food and Drug Administration (FDA) has not approved any novel anxiolytic pharmaceuticals, leading to increased interest in nutritional supplements as alternative therapies for stress management.
Purpose: Building on our previous study, this work aims to investigate the synergistic effects of Theanine (Th) and Walnut Peptide (WP) on stress mitigation and cognitive enhancement.