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Article Abstract
Objective: Hearing loss has been identified as a major modifiable risk factor for cognitive decline. The Early Age-Related Hearing Loss Investigation (EARHLI) study will assess the mechanisms linking early age-related hearing loss (ARHL) and cognitive impairment.
Study Design: Randomized, controlled, single-site, early phase II, superiority trial.
Setting: Tertiary academic medical center.
Participants: One hundred fifty participants aged 55 to 75 years with early ARHL (severity defined as borderline to moderate) and amnestic mild cognitive impairment will be included.
Interventions: Participants will be randomized 1:1 to a best practice hearing intervention or a health education control.
Main Outcome Measures: The primary study outcome is cognition measured by the Alzheimer Disease Cooperative Study-Preclinical Alzheimer Cognitive Composite. Secondary outcomes include additional measures of cognition, social engagement, and brain organization/connectivity.
Results: Trial enrollment will begin in early 2024.
Conclusions: After its completion in 2028, the EARHLI trial should offer evidence on the effect of hearing treatment versus a health education control on cognitive performance, social engagement, and brain organization/connectivity in 55- to 75-year-old community-dwelling adults with early ARHL and amnestic mild cognitive impairment.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11093050 | PMC |
| http://dx.doi.org/10.1097/MAO.0000000000004093 | DOI Listing |
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