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http://dx.doi.org/10.1016/j.gendis.2024.101303 | DOI Listing |
J Hum Evol
August 2025
Department of Biology, Faculty of Science, Ege University, Bornova, 35040 Izmir, Türkiye; Natural History Research & Application Center, Ege University, Bornova, 35040 Izmir, Türkiye.
Known for over a century, the Late Miocene mammalian faunas of Veles, North Macedonia, have long been recognized for their scientific importance. However, hominid remains had not been previously reported from this fossil-rich area. Here, we report the discovery of an isolated upper molar from the vicinity of Veles-most likely from the Belushka locality-which constitutes the first known record of a Late Miocene hominid from the Republic of North Macedonia, and provide a review of the associated mammalian assemblages.
View Article and Find Full Text PDFJ Dent Res
July 2025
Stomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials
The retreatment of failed adhesive restorations consumes more than 60% of clinical resources. Patient factors-such as caries risk, oral hygiene, diet, and occlusal stress-contribute to failure primarily. However, the contribution of the degradation of the adhesive-dentin interface to the failure cannot be ignored and involves 3 interrelated challenges: (1) highly hydrated demineralized dentin matrix (DDM) hindering adhesive infiltration, particularly in the partially demineralized zone; (2) residual hydroxyapatite (HAP) prone to dissolution; and (3) degradation of unprotected collagen by acid-activated matrix metalloproteinases (MMPs) and colonized microbes.
View Article and Find Full Text PDFCase Rep Dent
July 2025
Department of Oral Medicine and Pathology, Postgraduate and Research Division, Dental School, National Autonomous University of Mexico, Mexico City, Mexico.
Odontodysplasia is a dental anomaly that affects the maturation and formation of teeth, resulting in hypoplasia and hypocalcification of both enamel and dentin. It can affect one or several quadrants of the dentition, although generalized involvement is extremely rare. The exact cause is unclear, but trauma, infection, and nutritional or metabolic deficiencies have been suggested as possible contributing factors.
View Article and Find Full Text PDFCureus
May 2025
Graduate Program in Integrated Dental Sciences, Universidade de Cuiabá, Cuiabá, BRA.
Regional odontodysplasia (RO) is a rare dental anomaly that affects the development of dental tissues, resulting in amorphous, hypocalcified, hypoplastic teeth with the characteristic radiographic appearance of "ghost teeth." This study aims to report the clinical case of a patient diagnosed with RO in primary teeth. A two-year-old boy was brought to a private clinic with complaints of delayed eruption and anomalies in the upper right primary teeth.
View Article and Find Full Text PDFFront Cell Dev Biol
June 2025
Institute of Human Genetics, Biocenter, University of Würzburg, Würzburg, Germany.
Introduction: Besides skeletal symptoms, dental abnormalities are a typical feature of the rare inherited disorder hypophosphatasia (HPP), which is caused by loss of function mutations in the gene (alkaline phosphatase, biomineralization associated) coding for tissue-nonspecific alkaline phosphatase (TNAP). Dental symptoms include premature loss of deciduous teeth, disturbance in dentin and cementum mineralization, and an increased risk for periodontitis. However, the underlying molecular mechanisms are not fully understood and experimental cell lines for analyses of these processes are missing.
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