Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Hydrogen-bonded organic frameworks (HOF) represent an emerging category of organic structures with high crystallinity and metal-free, which are not commonly observed in alternative porous organic frameworks. These needle-like porous structure can help in stabilizing enzymes and allow transfer of molecules between enzymes participating in cascade reactions for enhanced substrate channelling. Herein, we systematically synthesized and investigated the stability of HOF at extreme conditions followed by one-pot encapsulation of single and bi-enzyme systems. Firstly, we observed HOF to be stable at pH 1 to 14 and at high temperatures (up to 115 °C). Secondly, the encapsulated glucose oxidase enzyme (GOX) showed 80 % and 90 % of its original activity at 70 °C and pH 11, respectively. Thirdly, transient time close to 0 seconds was observed for HOF encapsulated bi-enzyme cascade reaction system demonstrating a 4.25-fold improvement in catalytic activity when compared to free enzymes with enhanced substrate channelling. Our findings showcase a facile system synthesized under ambient conditions to encapsulate and stabilize enzymes at extreme conditions.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/chem.202401256 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Recent Advances in Metal-Organic Frameworks for Electromagnetic Wave Absorption.
Research (Wash D C)
September 2025
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), School of Materials Science and Engineering, Shandong University, Jinan 250061, China.
With the rapid advancement of communication technologies, issues of electromagnetic pollution and electromagnetic compatibility have become increasingly severe, heightening the demand for high-performance electromagnetic wave absorption materials. Metal-organic frameworks (MOFs) have flourished in this field owing to their chemical tunability, high porosity, tailored topological structures, and functionality. MOF-derived composites exhibit diverse loss mechanisms and heterogeneous structures, achieving lightweight, broadband, and highly efficient absorption.
View Article and Find Full Text PDFBioinspired wearable polymer microneedle patches: pioneering diabetic wound therapy for the horizon.
RSC Adv
September 2025
School of Pharmaceutical Sciences, Nanjing Tech University Nanjing 211816 China
Diabetic wounds present persistent challenges due to impaired healing, recurrent infection, oxidative stress, and dysregulated glucose metabolism. Bioinspired polymeric microneedle (MN) patches have emerged as multifunctional platforms capable of penetrating the stratum corneum to deliver therapeutics directly into the dermis, enabling glucose regulation, antimicrobial action, reactive oxygen species (ROS) modulation, and proangiogenic stimulation. Recent experimental evidence has demonstrated that the integration of glucose oxidase-loaded porous metal-organic frameworks, photothermal nanomaterials, and antioxidant hydrogels within dissolvable MNs achieves synergistic bactericidal effects, accelerates collagen deposition, and enhances neovascularization in diabetic wound models.
View Article and Find Full Text PDFA comprehensive review and recent advances on isatin-based compounds as a versatile framework for anticancer therapeutics (2020-2025).
RSC Adv
September 2025
Department of Medicinal Chemistry, Faculty of Pharmacy, Galala University P. O. 43713 New Galala Egypt
Isatin (1-indole-2,3-dione) is a privileged nitrogen-containing heterocyclic framework that has received considerable attention in anticancer drug discovery owing to its general biological behavior and structural diversity. This review focuses on isatin-heterocyclic hybrids as a valuable model in the development of new anti-cancer drugs that may reduce side effects and help overcome drug resistance, discussing their synthetic approaches and mechanism of action as apoptosis induction through kinase inhibition. With various chemical modifications, isatin had an excellent ability to build powerful isatin hybrids and conjugates targeting multiple oncogenic pathways.
View Article and Find Full Text PDFStructure and function of the topsoil microbiome in Chinese terrestrial ecosystems.
Front Microbiol
August 2025
State Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou, China.
While soil microorganisms underpin terrestrial ecosystem functioning, how their functional potential adapts across environmental gradients remains poorly understood, particularly for ubiquitous taxa. Employing a comprehensive metagenomic approach across China's six major terrestrial ecosystems (41 topsoil samples, 0-20 cm depth), we reveal a counterintuitive pattern: oligotrophic environments (deserts, karst) harbor microbiomes with significantly greater metabolic pathway diversity (KEGG) compared to resource-rich ecosystems. We provide a systematic catalog of key functional genes governing biogeochemical cycles in these soils, identifying: 6 core CAZyme genes essential for soil organic carbon (SOC) decomposition and biosynthesis; 62 nitrogen (N)-cycling genes (KOs) across seven critical enzymatic clusters; 15 sulfur (S)-cycling genes (KOs) within three key enzymatic clusters.
View Article and Find Full Text PDFAdjusting interlayer interactions and proton-conduction pathways of 2D covalent organic frameworks through the rotaxane structures.
Natl Sci Rev
September 2025
Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials, Department of Chemistry, University of Science and Technology Beijing, Beijing 100083, China.
Covalent organic frameworks (COFs) have great potential as versatile platforms for proton conduction. However, the commonly applied 2D COFs that are easy to design and synthesize have only 1D channels for proton conduction, limiting the formation of continuous hydrogen bonds due to the anisotropy between their crystalline grains. Herein, we report a strategy to construct 3D channels in 2D COFs by using rotaxane structures and eliminate the strong interlayer π-π interactions, facilitating the formation of smooth 3D proton-transfer pathways during guest doping.
View Article and Find Full Text PDF