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Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device. | LitMetric
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Evaluation of aconitine cardiotoxicity with a heart-on-a-particle prepared by a microfluidic device.

Tong Xu , Zengnan Wu , Hongren Yao , Yingrui Zhang , Shiyu Chen , Yuxuan Li , Xian-Li Meng , Yi Zhang , Jin-Ming Lin

Chem Commun (Camb)

Beijing Key Laboratory of Microanalytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Published: May 2024

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Article Abstract

A heart-on-a-particle model based on multicompartmental microgel is proposed to simulate the heart microenvironment and study the cardiotoxicity of drugs. The relevant microgel was fabricated by a biocompatible microfluidic-based approach, where heart function-related HL-1 and HUVEC cells were arranged in separate compartments. Finally, the mechanism of aconitine-induced heart toxicity was elucidated using mass spectrometry and molecular biotechnology.

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 Source
http://dx.doi.org/10.1039/d4cc00396aDOI Listing

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