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We present a novel method for analysing socio-spatial segregation in cities by considering constraints imposed by transportation networks. Using a multilayered network approach, we model the interaction probabilities of socio-economic groups with random walks and Lévy flights. This method allows for evaluation of new transport infrastructure's impact on segregation while quantifying each network's contribution to interaction opportunities. The proposed random walk segregation index measures the probability of individuals encountering diverse social groups based on their available means of transit via random walks. The index incorporates temporal constraints in urban mobility with a parameter, , of the probability of the random walk continuing at each time step. By applying this to a toy model and conducting a sensitivity analysis, we explore how the index changes dependent on this temporal constraint. When the parameter equals zero, the measure simplifies to an isolation index. When the parameter approaches one it represents the city's overall socio-economic distribution by mirroring the steady-state of the random walk process. Using Cuenca, Ecuador as a case study, we illustrate the method's applicability in transportation planning as a valuable tool for policymakers, addressing spatial distribution of socio-economic groups and the connectivity of existing transport networks, thus promoting equitable interactions throughout the city.
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http://dx.doi.org/10.1038/s41598-024-58932-9 | DOI Listing |
PLoS One
September 2025
Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.
Stroke significantly contributes to long-term disability, one of the problems is with impaired balance control, increasing the risk of falls. The risk of falls may be mitigated using reactive balance training (RBT) which has been shown to effectively reduce fall risk by enhancing reactive stepping following repeated balance perturbations. However, the optimal RBT intensity for people with chronic stroke remains unknown.
View Article and Find Full Text PDFPhysiother Theory Pract
September 2025
School of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC.
Background: Knee osteoarthritis (OA) causes pain and diminishes quality of life. Backward walking exercise (BWE) has been shown to improve lower muscle strength and reduce knee adduction moment, making it a recommended intervention for knee OA rehabilitation. This study aims to evaluate the effectiveness of BWE combined with conventional rehabilitation programs on pain intensity and disability among individuals with knee OA.
View Article and Find Full Text PDFEur J Heart Fail
September 2025
Cardiology Department, University Medical Centre Ljubljana, Ljubljana, Slovenia.
Aims: There is a lack of data from randomized clinical trials comparing treatment outcomes between conduction system pacing (CSP) modalities and biventricular pacing (BVP) in symptomatic patients with refractory atrial fibrillation (AF) scheduled for atrioventricular node ablation (AVNA). The CONDUCT-AF investigates whether CSP is non-inferior to BVP in improving left ventricular ejection fraction (LVEF) and clinical outcomes in heart failure (HF) patients with symptomatic AF undergoing AVNA.
Methods: This study is an investigator-initiated, prospective, randomized, multicentre clinical trial conducted across 10 European centres, enrolling 82 patients with symptomatic AF, HF with reduced LVEF, and narrow QRS.
J Gerontol A Biol Sci Med Sci
September 2025
Institute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Background: Ambulatory older residents in long-term care(LTC) have the highest risk of falling. However, the relationship between ambulatory activity (steps per day) and fall risk in LTC is unclear. This study examined whether baseline daily step count, functional capacity and cognitive function predicted falls in LTC residents, and whether functional capacity modified the relationship between step count and fall risk.
View Article and Find Full Text PDFIntegr Med Res
March 2026
Department of Acupuncture and Moxibustion Medicine, Pusan National University Korean Medicine Hospital, Yangsan, Republic of Korea.
Background: In the clinical practice of Korean Medicine, pharmacopuncture therapy and acupotomy (PA) are being increasingly explored as potential treatment options for degenerative lumbar spinal stenosis (LSS). In this study, we aimed to evaluate the effectiveness and safety of combining PA with conventional Korean Medicine treatment (CKMT) in patients with degenerative LSS.
Methods: A pragmatic, assessor-blinded, randomized controlled trial was conducted with 104 participants aged 40-75 years diagnosed with degenerative LSS.