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http://dx.doi.org/10.1055/a-2255-7184 | DOI Listing |
Cold Spring Harb Perspect Med
August 2025
Department of Clinical Neurosciences, University of Cambridge, Cambridge CB2 2PY, United Kingdom
Since the publication of our article "Dopamine Cell-Based Replacement Therapies" (Kayhanian and Barker. 2025. doi:10.
View Article and Find Full Text PDFImplement Sci
August 2025
VA Center for Healthcare Evaluation, Research, and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Background: The Consolidated Framework for Implementation Research (CFIR) is a determinant framework that includes constructs from many implementation theories, models, and frameworks; it is used to predict or explain barriers and facilitators to implementation success. CFIR is among the most widely applied implementation science frameworks, and after 15 years of use in the field, the framework was updated based on user feedback obtained via literature review and survey. Dissemination of the updated CFIR and accompanying outcomes addendum resulted in hundreds of requests from users for further guidance in applying the framework.
View Article and Find Full Text PDFAust Crit Care
August 2025
Department of Critical Care, Melbourne Medical School, The University of Melbourne, Australia; Department of Intensive Care, Melbourne Health, Melbourne, Australia.
Background: Peer support is a candidate intervention to improve health-related quality of life in survivors of critical illness. This trial will evaluate the effect of a codesigned digital peer support intervention (expert-facilitated, web-based peer support) compared to usual care.
Design: This study is planned as a randomised, multicentre, two-arm, parallel-group (1:1) hybrid effectiveness implementation trial of a digital peer support model versus usual care.
Lakartidningen
August 2025
professor, socialmedicinare; enhetschef, Läkemedelsverket.
The daily regulatory work with pharmacovigilance includes requirements of risk minimisation measures (RMM). However, when it comes to evaluating the efficacy of RMM, methodological issues have been raised regarding commonly used surveys, and the updated Guideline on good pharmacovigilance practices, Module XVI Addendum II, proposes using mixed methods when RMM outcome is evaluated. The Swedish Medical Products Agency has used aggregated national register data to evaluate compliance to the contraindication for cyproterone in patients with previous or current meningioma.
View Article and Find Full Text PDFFront Health Serv
April 2025
Geriatric Education & Research Institute, Singapore, Singapore.
Introduction: Older adults are at increased risk of experiencing multimorbidity and care dependency due to declines in their physiological reserves. Optimizing the intrinsic capacity and functional ability of individuals is important to enable healthy aging. We engaged potential implementers of an integrated, community-based model for frailty and intrinsic capacity care, adapted from the World Health Organization Integrated Care for Older People framework, to assess the anticipated barriers and enablers to implementation within Singapore's healthcare context.
View Article and Find Full Text PDF