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http://dx.doi.org/10.1242/jeb.247699 | DOI Listing |
PLoS One
September 2025
[This corrects the article DOI: 10.1371/journal.pone.
View Article and Find Full Text PDFJ Telemed Telecare
September 2025
Centre for Innovative Medical Technology, Odense University Hospital, Odense, Denmark.
IntroductionThe use of digital solutions including patient-reported outcomes is limited to follow-up of patients with established diagnoses but is rarely used as first step of the diagnostic process substituting a personal contact with a health professional. We report on the diagnostic validity and cost per patient implications based on a feasibility study of a new virtual diagnostic service (VDS) for common neurological sleep disorders that, as a first step, involves the collection and automated analysis of self-reported digital patient data.MethodsThe VDS was established at the Odense University Hospital, Denmark.
View Article and Find Full Text PDFPrev Med Rep
October 2025
Guangxi Orthopedic Hospital, Nanning 530012, China.
Objective: Negative emotions during adolescence constitute a significant public health challenge requiring theoretically-grounded intervention approaches. This investigation examined sequential mediation mechanisms whereby physical exercise influences adolescent negative emotions through psychological benefits and social self-efficacy pathways, integrating neurobiological and social-cognitive theoretical frameworks.
Methods: Cross-sectional analysis of 1471 Chinese adolescents (Mean age = 13.
J Med Imaging (Bellingham)
September 2025
Vanderbilt University, Data Science Institute, Nashville, Tennessee, United States.
Purpose: Recent developments in computational pathology have been driven by advances in vision foundation models (VFMs), particularly the Segment Anything Model (SAM). This model facilitates nuclei segmentation through two primary methods: prompt-based zero-shot segmentation and the use of cell-specific SAM models for direct segmentation. These approaches enable effective segmentation across a range of nuclei and cells.
View Article and Find Full Text PDFNAR Genom Bioinform
September 2025
DNA Repair and Recombination Laboratory, St Vincent's Institute of Medical Research, Fitzroy VIC 3065, Australia.
Meiotic crossovers promote correct chromosome segregation and the shuffling of genetic diversity. However, the measurement of crossovers remains challenging, impeding our ability to decipher the molecular mechanisms that are necessary for their formation and regulation. Here we demonstrate a novel repurposing of the single-nucleus Assay for Transposase Accessible Chromatin with sequencing (snATAC-seq) as a simple and high-throughput method to identify and characterize meiotic crossovers from haploid testis nuclei.
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