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Article Abstract
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11290539 | PMC |
| http://dx.doi.org/10.3324/haematol.2024.285031 | DOI Listing |
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Features that characterize monoclonal light chain ("myeloma") cast nephropathy with immunofluorescence challenges and emphasis on electron microscopy.
Ultrastruct Pathol
September 2024
Department of Pathology and Interdisciplinary Clinical Oncology, University of South Alabama, Mobile, AL, USA.
Renal disease is a common cause of morbidity and mortality in patients with plasma cell dyscrasias. The serum-free light chain assay is used in patients, mostly older, with unexplained acute kidney injury to screen for potential myeloma cast nephropathy. This study consists of a systematic review of diagnostic features in myeloma cast nephropathy.
View Article and Find Full Text PDFNon-myeloma light chain cast nephropathy: a multicenter retrospective study on clinicopathological characteristics.
Haematologica
August 2024
Department of Pathology, Necker-Enfants Malades and Robert Debré University Hospital, APHP, Paris, France; Paris-Cité University, Paris.
Article Synopsis
- The study investigates kidney biopsies with diffuse monoclonal light chain staining, highlighting the challenges in diagnosing MIg-associated kidney disease, as findings can vary significantly and lead to misdiagnosis or unnecessary treatment.* -
- Out of 32 cases analyzed, nearly half (47%) had active myeloma requiring immediate treatment, while some patients showed no myeloma, illustrating the complexity of interpreting biopsy results.* -
- The authors stress the need for detailed hematologic evaluations and recommend ongoing monitoring to identify any malignant changes while avoiding inappropriate treatments for patients without active myeloma.*
Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test.
BMC Nephrol
July 2017
Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, B15 2TT, Birmingham, UK.
Background: Acute kidney injury (AKI) is common in patients with multiple myeloma (MM). Whether serum free light chain (sFLC) measurements can distinguish between myeloma and other causes of AKI requires confirmation to guide early treatment. A rapid and portable sFLC test (Seralite®) is newly available and could reduce delays in obtaining sFLC results and accelerate diagnosis in patients with unexplained AKI.
View Article and Find Full Text PDFMutational landscape reflects the biological continuum of plasma cell dyscrasias.
Blood Cancer J
February 2017
Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum/University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
We subjected 90 patients covering a biological spectrum of plasma cell dyscrasias (monoclonal gammopathy of undetermined significance (MGUS), amyloid light-chain (AL) amyloidosis and multiple myeloma) to next-generation sequencing (NGS) gene panel analysis on unsorted bone marrow. A total of 64 different mutations in 8 genes were identified in this cohort. NRAS (28.
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