Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Crohn's disease (CD) is a chronic inflammatory disease that leads to intestinal stricture in nearly 35% of cases within 10 years of initial diagnosis. The unknown pathogenesis, lack of universally accepted criteria, and absence of an effective management approach remain unconquered challenges in structuring CD. The pathogenesis of stricturing CD involves intricate interactions between factors such as immune cell dysbiosis, fibroblast activation, and microecology imbalance. New techniques such as single-cell sequencing provide a fresh perspective. Non-invasive diagnostic tools such as serum biomarkers and novel cross-sectional imaging techniques offer a precise understanding of intestinal fibrostenosis. Here, we provide a timely and comprehensive review of the worthy advancements in intestinal strictures in 2023, aiming to dispense cutting-edge information regarding fibrosis and to build a cornerstone for researchers and clinicians to make greater progress in the field of intestinal strictures.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250166 | PMC |
| http://dx.doi.org/10.1002/ueg2.12568 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"Cut and Cover": A Case Series of Dual Modality Treatment With Stricturetomy and Stenting for Inflammatory Bowel Disease-Related Strictures.
Cureus
August 2025
Gastroenterology and Hepatology Division of the Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
Strictures are common in inflammatory bowel disease (IBD) and are managed medically and endoscopically, if feasible, due to the risk of surgical complications. While endoscopic balloon dilation (EBD) is often successful, the need for repeat dilation and subsequent surgery is common. Endoscopic stricturotomy (ESt) has gained popularity but has been limited by frequent post-procedural bleeding.
View Article and Find Full Text PDFMissed strictures and penetrating complications on CT and MR enterography in Crohn's disease patients prior to anti-TNF therapy.
Abdom Radiol (NY)
September 2025
Department of Radiology, Mayo Clinic, Rochester, USA.
Purpose: Crohn's disease (CD) is characterized by enteric inflammation, often resulting in strictures and penetrating complications, which may alter patient management prior to the initiation of biologic therapy. Our aim is to assess the frequency of missed stricturing and internal penetrating complications in CD patients on computed tomography enterography (CTE) and magnetic resonance enterography (MRE) performed prior to anti-TNF therapy.
Methods: We retrospectively reviewed patients from two tertiary centers who underwent CTE\MRE within six months before starting anti-TNF therapy.
Advances in diagnosis and therapy for upper gastrointestinal Crohn's disease.
Curr Opin Gastroenterol
August 2025
Yale University, Section of Digestive Diseases, New Haven, Connecticut, USA.
Purpose Of Review: Crohn's disease is a chronic, relapsing and remitting inflammatory process that can involve the entire length of the gastrointestinal tract. Upper gastrointestinal involvement (UGI) in Crohn's disease is present in up to 15% of patients and can present as a diagnostic challenge given nonspecific symptoms and overlapping disease entities. This review provides an update on diagnosing and risk stratifying UGI-CD.
View Article and Find Full Text PDFPrevalence of sacroiliitis on magnetic resonance enterography in Crohn's disease and its association with intestinal findings: a monocentric observational cross-sectional study.
Clin Exp Med
September 2025
Chair of Rheumatology, University Hospital of Modena, University of Modena and Reggio Emilia, Policlinico Di Modena, Via del Pozzo, 71, 41125, Modena, Italy.
Magnetic resonance enterography (MRE) is recommended for the assessment of small intestine alterations in Crohn's disease (CD). Sacroiliac joints (SIJs) imaging has a central role in the early diagnosis of sacroiliitis (SI). MRE can evaluate both acute and structural findings of SIJs.
View Article and Find Full Text PDFFamilial Mediterranean fever (FMF) complicated by adhesive small bowel obstruction: a diagnostic challenge.
BMJ Case Rep
September 2025
Surgical, Nottingham University Hospitals NHS Trust-City Campus, Nottingham, Nottinghamshire, UK.
Familial Mediterranean fever (FMF) is an autosomal recessive auto-inflammatory disorder that primarily affects individuals of Mediterranean, Middle Eastern and South Asian origin . We report the case of a male patient in his late 20s who was diagnosed with FMF at the age of 17 years. Prior to the diagnosis, he underwent two unnecessary surgical interventions due to recurrent episodes of acute abdominal pain-an appendectomy, followed 3 years later by a negative exploratory laparotomy for suspected adhesive small bowel obstruction (SBO).
View Article and Find Full Text PDF