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To evaluate the relationship between sleep problems and psychopathologies in Brazilian preschool children. The present is a cross-sectional study with162 children: 81 with sleep problems referred for treatment (mean age: 3.67 years), matched by gender/age with 81 participants without sleep problems. Sleep problems were identified through a clinical interview with a specialist. Psychopathologies were evaluated using the Child Behavior Checklist for Ages 1.5-5 (CBCL/1.5-5). Having sleep problems was a predictor of all forms of psychopathologies on the CBCL scales, except for the withdrawn scale. Aggressive behavior, depression/anxiety, affective problems, and oppositional defiant disorder were associated with presence of sleep problems. Given the probable bidirectionality of the association between sleep problems and psychopathologies in children, it is suggested that regular assessments of both phenomena should be performed in children referred for treatment of sleep problems and mental health problems in general.
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http://dx.doi.org/10.1055/s-0043-1777786 | DOI Listing |
Cancer Rep (Hoboken)
September 2025
Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Centre of Soochow University, Suzhou, Jiangsu, China.
Background: Epigenetic regulation significantly affects immune responses in lung adenocarcinoma (LUAD). However, the role of RNA N6-methyladenosine (m6A) modification, especially in obstructive sleep apnea-hypopnea syndrome (OSAHS) within LUAD, is not well understood.
Methods: This study examined m6A modification patterns in 973 LUAD patients using 23 regulatory genes.
Nan Fang Yi Ke Da Xue Xue Bao
August 2025
Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen 518101, China.
Objectives: To investigate the therapeutic effect of acupuncture in a rat model of insomnia and its regulatory effect on the glutamic acid (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic loop.
Methods: Forty male SD rats were randomly assigned to control group, model group, group and group (=10). In the latter 3 groups, rat models of insomnia were established by intraperitoneal injections of p-chlorophenylalanine and verified using a sodium pentobarbital-induced sleep test.
Nihon Eiseigaku Zasshi
September 2025
Department of Hygiene, Public Health and Preventive Medicine, Showa Medical University School of Medicine, Tokyo, Japan.
Objective: In this study, we aimed to examine the relationship between the Eating Assessment Tool-10 (EAT10) score, a screening index for dysphagia, and the Epworth Sleepiness Scale (ESS) score, which evaluates daytime sleepiness in Japanese workers.
Method: A cross-sectional study of 496 workers (454 men and 42 women) at two business locations in Japan was conducted from November 2021 to June 2022. Dysphagia was assessed using the score of EAT10, a self-administered questionnaire.
Sleep Med Clin
September 2025
Parkinson Foundation Centre of Excellence, King's College Hospital and King's College, London, United Kingdom; King's College Hospital, London, Dubai, UAE; Institute of Psychiatry, Psychology and Neuroscience, King's College, Dementech Clinical Neuroscience Centre London, United Kingdom. Electronic
Personalized medicine (PM) for Parkinson's disease (PD) can range from precision genomic therapies such as ambroxol in glucocerebrosidase mutation-linked PD to treatment tailored for sleep dysfunction in nonmotor subtypes of PD. Additionally, in future pharmacogenetics may also play a part by identification of PD patients susceptible to specific sleep problems such as sudden onset of sleep and facilitate avoiding drugs that may cause these side effects. Age, physical exercise, comorbidities can also drive quality of sleep in PD and form important part of the Parkinson's dashboard-led strand of PM.
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September 2025
Parkinson Foundation Centre of Excellence, King's College Hospital and King's College, London, United Kingdom; King's College Hospital, London, Dubai, UAE; Institute of Psychiatry, Psychology and Neuroscience, King's College, Dementech Clinical Neuroscience Centre London, United Kingdom. Electronic
Sleep dysfunction can affect almost 90% of Parkinson's disease (PD) patients and insomnia related to fragmented sleep is common. Satisfactory management remains an unmet need although dopaminergic non-oral treatments utilising a continuous drug delivery strategy appears to help sleep maintenance insomnia. Transdermal therapy with rotigotine or subcutaneous apomorphine infusion is effective while recent data show considerable efficacy of intrajejunal or subcutaneous levodopa infusion on alleviation of insomnia in PD.
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