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A recent study by Cheung, Pauler, Koppensteiner et al. combining lineage tracing with single-cell RNA sequencing (scRNA-seq) has revealed unexpected features of the developing superior colliculus (SC). Extremely multipotent individual progenitors generate all types of SC neurons and glial cells that were found to localize in a non-predetermined pattern, demonstrating a remarkable degree of unpredictability in SC development.
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http://dx.doi.org/10.1016/j.tins.2024.03.001 | DOI Listing |
Diagn Pathol
September 2025
Department of Gastrointestinal Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
Background: Gastric cancer is one of the most common cancers worldwide, with its prognosis influenced by factors such as tumor clinical stage, histological type, and the patient's overall health. Recent studies highlight the critical role of lymphatic endothelial cells (LECs) in the tumor microenvironment. Perturbations in LEC function in gastric cancer, marked by aberrant activation or damage, disrupt lymphatic fluid dynamics and impede immune cell infiltration, thereby modulating tumor progression and patient prognosis.
View Article and Find Full Text PDFBMC Plant Biol
September 2025
Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, 72388, Saudi Arabia.
Drought stress affects plant growth and production. To cope with drought stress, plants induced physiological and metabolic changes, serving as a protective approach under drought-stress conditions. The response to drought can vary based on plant type (C3 vs.
View Article and Find Full Text PDFACS Appl Mater Interfaces
September 2025
Affiliated Hospital of Shandong Second Medical University, Shandong Second Medical University, Weifang, Shandong 261053, P.R. China.
Decades of antibiotic misuse have spurred an antimicrobial resistance crisis, creating an urgent demand for alternative treatment options. Although phototherapy has therapeutic potential, the efficacy of the most advanced photosensitizers (PS) is essentially limited by aggregation-induced quenching, which significantly reduces their therapeutic effect. To address these challenges, we developed a cationic metallocovalent organic framework (CRuP-COF) via a solvent-mediated dual-reaction synthesis strategy.
View Article and Find Full Text PDFActa Ortop Mex
September 2025
Instituto Nacional de Rehabilitación «Luis Guillermo Ibarra Ibarra». Ciudad de México. México.
Rotator cuff injuries are common and procedures of repair have evolved from open techniques to minimally invasive and arthroscopic ones. Despite these advances, the biomechanics, biology, and value of transosseous repairs remain superior, leading to the development of innovative devices that enable the utilization of this technique without the use of anchors, improving both the efficiency and safety of the procedure. This article reviews the latest advances in transosseous rotator cuff repair, highlighting its biomechanical advantages, as well as the factors that enhance recovery and offer more consistent long-term outcomes.
View Article and Find Full Text PDFISA Trans
September 2025
School of Astronautics, Harbin Institute of Technology, Harbin, China. Electronic address:
For space missions such as extraterrestrial sample collection, robotic rover exploration, and astronaut landings, the complex terrain and diverse gravitational environments make ground-based micro-low-gravity experimental systems essential for testing and validating spacecraft performance as well as supporting astronaut training. The suspended gravity unloading (SGO) system is a key device commonly used to simulate micro-low-gravity environments. However, the SGO system faces challenges due to model uncertainty and external disturbances, which limit improvements in control accuracy.
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