Supermultipotency and unpredictability in the developing superior colliculus.

Trends Neurosci

Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA. Electronic address:

Published: April 2024


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Article Abstract

A recent study by Cheung, Pauler, Koppensteiner et al. combining lineage tracing with single-cell RNA sequencing (scRNA-seq) has revealed unexpected features of the developing superior colliculus (SC). Extremely multipotent individual progenitors generate all types of SC neurons and glial cells that were found to localize in a non-predetermined pattern, demonstrating a remarkable degree of unpredictability in SC development.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047761PMC
http://dx.doi.org/10.1016/j.tins.2024.03.001DOI Listing

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