Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Percutaneous cholangioscopy (PerC) offers an alternative for patients with an inaccessible biliary tree. This systematic review and meta-analysis aimed to evaluate the performance of this technique.
Methods: A search in Medline, Cochrane and ClinicalTrials.gov databases was performed for studies assessing PerC up to October 2022. The primary outcome was diagnostic success, defined as successful stone identification or stricture workup. Secondary outcomes included therapeutic success (stone extraction, stenting) and complication rate. A subgroup analysis compared previous-generation and modern cholangioscopes. We performed meta-analyses using a random-effects model and the results were reported as percentages with 95% confidence interval (CI).
Results: Fourteen studies (682 patients) were eligible for analysis. The rate of diagnostic success was 98.7% (95%CI 97.6-99.8%; =31.19%) and therapeutic success was 88.6% (95%CI 82.8-94.3%; =74.92%). Adverse events were recorded in 17.1% (95%CI 10.7-23.5%; =77.56%), of which 15.9% (95%CI 9.8-21.9%; =75.98%) were minor and 0.6% (95%CI 0.1-1.2%; =0%) major. The Spyglass system showed null heterogeneity for all outcomes; compared with older-generation endoscopes it offered comparable diagnostic success, but yielded significantly superior therapeutic success (96.1%, 95%CI 90-100%; =0% vs. 86.4%, 95%CI 79.2-93.6%; =81.41%; P=0.02].
Conclusion: PerC, especially using currently available cholangioscopes, is associated with high diagnostic and therapeutic success.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10927623 | PMC |
| http://dx.doi.org/10.20524/aog.2024.0869 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
All Roads Lead to Carbinolamine: QM/MM Study of Enzymatic C-N Bond Cleavage in Anaerobic Glycyl Radical Enzyme Choline Trimethylamine-Lyase (CutC).
J Phys Chem B
September 2025
Centre for Computational Chemistry, School of Chemistry, University of Bristol, Bristol BS8 1TS, U.K.
The anaerobic glycyl radical enzyme choline trimethylamine-lyase (CutC) is produced by multiple bacterial species in the human gut microbiome and catalyzes the conversion of choline to trimethylamine (TMA) and acetaldehyde. CutC has emerged as a promising therapeutic target due to its role in producing TMA, which is subsequently oxidized in the liver to form trimethylamine--oxide (TMAO). Elevated TMAO levels are associated with several human diseases, including atherosclerosis and other cardiovascular disorders─a leading cause of mortality worldwide.
View Article and Find Full Text PDFRe-do VATS for recurrent pneumothorax in a Birt-Hogg-Dubé syndrome patient.
Multimed Man Cardiothorac Surg
September 2025
Institute of Chest Surgery, Medanta, Gurugram, India
Birt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant inherited disorder caused by mutation in a tumour suppressor gene, FLCN, leading to skin tumours (fibrofolliculomas), renal tumours and pulmonary cysts. Lung involvement is predominantly observed in 70% of the cases of BHDS, manifesting in the form of recurrent primary spontaneous pneumothorax. This video tutorial showcases the surgical management of recurrent right primary spontaneous pneumothorax in a young adult with a history of multiple episodes of bilateral pneumothorax managed by surgical intervention previously.
View Article and Find Full Text PDFMulti drug resistant Pseudomonas aeruginosa in burn infection among Iraq patients.
Cell Mol Biol (Noisy-le-grand)
September 2025
Medical Microbiology Department, College of Medicine, Ibn Sina University of Medical and Pharmaceutical Sciences, Baghdad, Iraq.
Pseudomonas aeruginosa is a prominent opportunistic pathogen, especially in burn wound infections, and is often associated with high morbidity and mortality due to its multidrug resistance (MDR) characteristics.This study aimed to evaluate the multidrug resistance profile and perform a molecular phylogenetic analysis of P. aeruginosa isolates recovered from human burn infection sample .
View Article and Find Full Text PDFAccurate tacrolimus monitoring by dual peripherally inserted central catheters in allogeneic HSCT.
Int J Hematol
September 2025
Department of Hematology and Oncology, Asahikawa Red Cross Hospital, 1-1 Akebono-Cho, Asahikawa, Hokkaido, Japan.
Introduction: Allogeneic hematopoietic stem-cell transplantation (allo-HSCT) requires reliable vascular access for medication, transfusion, and blood sampling, which often involves painful venipuncture. This prospective study evaluated a novel dual peripherally inserted central venous catheter (PICC) technique to reduce venipuncture frequency in allo-HSCT recipients.
Methods: The study enrolled 29 allo-HSCT recipients.
Long-term outcomes of corneal patch grafts.
Cell Tissue Bank
September 2025
Medline Hospital, Adana, Turkey.
To evaluate long‑term outcomes of corneal patch grafting (CPG) and to determine prognostic factors for anatomical and functional success. This retrospective study included 35 eyes from 35 patients who underwent CPG between April 2016 and September 2022 at Adana City Training and Research Hospital. Collected data included age, sex, preoperative and postoperative best-corrected visual acuity (BCVA), graft localization and size, anterior segment findings, graft survival, secondary surgical procedures, and rates of anatomical and functional success.
View Article and Find Full Text PDF