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Background Bag-mask ventilation is an essential life-saving skill. The E-C technique of mask holding is the most popular. In patients with suspected cervical injury, the jaw thrust maneuver is recommended instead of the E-C technique with head tilt-chin lift. Should jaw thrust fail to produce adequate chest rise, the operator is advised to switch to the E-C technique with the head tilt-chin lift maneuver with head extension as it is vital to move oxygen into the lungs. We hypothesized that the E-C clamp with the head in the neutral position without head tilt might permit adequate ventilation without producing excessive movement of the cervical spine, which in turn might translate as less strain to the cervical spine. Methods In this prospective, randomized, double-blind, crossover study, we evaluated the relative efficacy of three airway maneuvers in opening the airway in anesthetized and paralyzed adults: jaw thrust, two-handed E-C technique with head in the neutral position, and two-handed E-C technique with head fully extended. The tidal volume generated during mechanical ventilation using these three techniques was considered as the primary outcome. Seventy-two subjects were recruited for this trial and all three techniques of mask holding were performed in each of these subjects in a sequence as dictated by a randomization table. Results The jaw thrust technique provided a mean tidal volume significantly higher than the two-handed E-C technique, with the head in the neutral position (p<0.001). Similarly, the two-handed E-C technique with the head fully extended provided a mean tidal volume significantly higher than the two-handed E-C technique with the head in neutral position (p<0.011). The mean tidal volume obtained with jaw thrust and two-handed E-C technique with head fully extended were comparable (p=0.78). Conclusion The two-handed E-C technique with the head fully extended, and the jaw thrust technique both produce good and comparable tidal volumes. The two-handed E-C technique with the head in a neutral position provides adequate though lower tidal volumes as compared to the other two techniques.
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http://dx.doi.org/10.7759/cureus.53791 | DOI Listing |
Hypertension
September 2025
School of Population Health, University of New South Wales, Sydney, Australia (A.E.S.).
Background: Blood pressure (BP) is a common clinical measurement, now increasingly done at home. Media websites often display images of BP measurement to represent clinical medicine, but many images deviate from guidelines, potentially creating misperceptions on how measurement should be performed. We evaluated the accuracy of BP measurement images online according to the 2023 International Consensus on Standardized Clinic BP Measurement.
View Article and Find Full Text PDFJ Infect
September 2025
Laboratoire de Parasitologie-Mycologie, Centre National de Référence des Mycoses et Antifongiques LA-AspC Aspergilloses chroniques, European Excellence Center for Medical Mycology (ECMM EC), Centre hospitalier Universitaire de Rennes, F-35000 Rennes, France; Univ Rennes, CHU Rennes, Inserm, EHESP,
Objectives: The aim of this work was to study the epidemiology of urogenital trichomoniasis in the setting of systematic screening of STIs, using a multiplex molecular assay. Besides, the specificity for T. vaginalis detection of the syndromic panel was assessed comparatively to an in-house PCR.
View Article and Find Full Text PDFStroke
September 2025
Department of Neurology, Yale University School of Medicine, New Haven, CT. (L.S.B.B., A.L.H., H.E.B., C.W.J., J.G., L.H.S.).
Background: Fingolimod is an immunomodulatory drug that has shown promising effects in stroke treatment, including improvements in neurofunctional recovery and a reduction in infarct size. Fingolimod modulates the sphingosine-1-phosphate receptors, which leads to the internalization of sphingosine-1-phosphate receptors on T and B lymphocytes, thereby preventing their egress from secondary lymphoid organs. Here, we report a secondary analysis from the Stroke Preclinical Assessment Network trial.
View Article and Find Full Text PDFiScience
September 2025
Arkansas Children's Research Institute, Little Rock, AR 72202, USA.
There is untapped potential for medical breakthroughs using engineered microbes to treat conditions such as those of the gastrointestinal tract. In this report, we explore the feasibility of established protein surface display methods to be used in the probiotic yeast to display antibodies within a simulated gastrointestinal environment. We demonstrate that an auxotrophic strain of this yeast derived directly from a commercial probiotic can express functional antibodies tethered to the cell surface.
View Article and Find Full Text PDFClin Microbiol Infect
August 2025
Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum, University of BolognaInfectious Diseases Unit, Forlì and Cesena Hospital, AUSL Romagna, Forlì and Cesena, Italy.
Scope: Interpretation of rapid and advanced microbiological test results remains nonstandardized, with no existing reference guidelines. This study aimed to analyze the existing evidence and provide expert guidance on the use of these techniques in critically ill patients.
Methods: A Delphi consensus process was conducted by a multidisciplinary panel of experts, including microbiologists, infectious disease specialists, intensivists, surgeons, and pulmonologists.