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http://dx.doi.org/10.1097/TXD.0000000000001602 | DOI Listing |
Chirurgia (Bucur)
August 2025
Ischemia time is a well-established determinant of liver transplant outcomes. Patient survival is substantially affected by prolonged warm (WIT) and cold ischemia time (CIT) of the graft during liver transplant. One component that may be a contributing factor to both WIT and CIT is back bench time (BBT).
View Article and Find Full Text PDFHepatobiliary Surg Nutr
August 2025
Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Background And Objective: Hemadsorption, a therapeutic modality traditionally used to mitigate cytokine storm in critically ill patients and is now being tested in other medical fields including organ transplantation, especially for organs from extended criteria donors. Such organs are susceptible to ischemia-reperfusion injury (IRI) during transplantation, which is known to release a cascade of innate immune mediators including damage-associated molecular patterns (DAMPs) and cytokines during reperfusion and ultimately leading to graft dysfunction based on the metabolic injury. To address this challenge, early studies have integrated hemadsorption filters into organ perfusion circuits, such as normothermic regional perfusion (NRP) in donors and machine perfusion (MP) of grafts, with the aim to reduce inflammation and improve organ viability.
View Article and Find Full Text PDFClin Transplant
August 2025
Department of Surgery, Division of HPB Surgery and Liver transplantation, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.
Liver transplantation is the treatment of choice for patients with end-stage liver disease. However, donor shortages have increased the use of high-risk and extended criteria donor livers, including livers donated after circulatory death and those with severe steatosis. Severe donor liver steatosis is associated with poor outcomes due to high susceptibility to ischemia-reperfusion injury.
View Article and Find Full Text PDFJ Surg Res
August 2025
School of Medicine, Mashhad University of Medical Science, Mashhad, Iran. Electronic address:
Yonsei Med J
September 2025
The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Ex vivo machine perfusion (EVMP) is increasingly recognized as a promising technique for enhancing the preservation and viability of donor organs, particularly in donation after circulatory death (DCD) liver transplantation (LT). This study validates a transplant surgeon-innovated EVMP protocol by assessing its efficacy in preserving liver function and reducing ischemia-reperfusion injury (IRI) in a porcine DCD-simulated liver transplant (DCD sLT) model.
Materials And Methods: Twenty Yorkshire pigs were used to compare static cold storage (SCS) and EVMP.