Unusual Enzymatic C-C Bond Formation and Cleavage Reactions during Natural Product Biosynthesis.

Chem Pharm Bull (Tokyo)

Graduate School of Pharmaceutical Sciences, The University of Tokyo.

Published: March 2024


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Article Abstract

Natural products from plants and microorganisms provide a valuable reservoir of pharmaceutical compounds. C-C bond formation and cleavage are crucial events during natural product biosynthesis, playing pivotal roles in generating diverse and intricate chemical structures that are essential for biological functions. This review summarizes our recent findings regarding biosynthetic enzymes that catalyze unconventional C-C bond formation and cleavage reactions during natural product biosynthesis.

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Source
http://dx.doi.org/10.1248/cpb.c23-00889DOI Listing

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