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Pediatricians have a critically important role in the care of children with autism, including conducting developmental screening to support early diagnosis and intervention, advising families about evidence-based treatments for autism spectrum disorder, and supporting families' emotional health as they care for a child with a developmental disability. The purpose of this article is to provide pediatricians with information about evidence-based autism treatments and how to determine which interventions are appropriate for children across the autism spectrum at different ages and developmental stages.
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http://dx.doi.org/10.1016/j.pcl.2024.01.001 | DOI Listing |
Disabil Rehabil Assist Technol
September 2025
Department of Health Sciences, European University Cyprus, Nicosia, Cyprus.
We examined the concurrent change in developmental language phase (DLP) and linguistic status of children with Autism Spectrum Disorder (ASD)/autism, identified as Nonverbal/Minimally-Verbal (NV/MV), utilizing Augmentative/Alternative Communication (AAC) systems. We compared the linguistic output of NV/MV autistic children concurrently, with and without use of AAC systems. Additionally, we compared the linguistic level, characteristics, and early developmental milestones for AAC users and non-users.
View Article and Find Full Text PDFMol Genet Genomics
September 2025
Human Phenome Institute, MOE Key Laboratory of Contemporary Anthropology, Zhangjiang Fudan International Innovation Center, Fudan University, 825 Zhangheng Road, Shanghai, 201203, China.
Accurate variant calling is essential for next-generation sequencing (NGS)-based diagnosis of rare diseases, yet most benchmarking studies have focused on standard cell lines or trio-based samples, with limited relevance to sporadic cases. Here, we systematically compared the performance of DeepVariant and GATK HaplotypeCaller in two Chinese cohorts of patients with sporadic epilepsy (EP) and autism spectrum disorder (ASD). DeepVariant exhibited higher precision and sensitivity in detecting single nucleotide variants (SNVs), while GATK showed a distinct advantage in identifying rare variants, which are often key to understanding the genetic basis of rare diseases.
View Article and Find Full Text PDFJ Autism Dev Disord
September 2025
Departamento de Didácticas Especiáis, Universidade de Vigo, 36310, Vigo, Spain.
Children and adolescents with Attention-Deficit/Hyperactivity Disorder (ADHD) are often reported to have motor skill deficits, though findings remain inconsistent across studies. To determine whether motor competence differs significantly between youth with ADHD and their typically developing (TD) peers through a systematic review and meta-analysis. Following PRISMA guidelines, four databases were searched up to May 2025.
View Article and Find Full Text PDFNeuropsychopharmacology
September 2025
Department of Psychiatry, Columbia University, New York, NY, USA.
Adv Child Dev Behav
September 2025
University of South Carolina, Columbia, SC, USA; Carolina Autism and Neurodevelopment Research Center, Columbia, SC, USA.
Autism spectrum disorder (ASD) unfolds over the first two years of life through complex interactions among developmental systems. Attention and autonomic nervous system (ANS) regulation represent foundational processes critical for adaptive engagement with the environment. Disruptions in these systems during early infancy may initiate developmental cascades that contribute to core ASD features, including social-communication challenges and restricted and repetitive behaviors, as well as the vast heterogeneity found within ASD.
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