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The Safe System Approach (SSA) has emerged as a comprehensive framework for enhancing traffic safety through system-wide interventions. This systematic review, conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, analyzes 82 relevant studies categorized based on the SSA pillars: safe road users, safe vehicles, safe speeds, safe roads, and post-crash care. The review provides insights into SSA's effectiveness in reducing road traffic fatalities and injuries, exploring implementation challenges and opportunities, including policy initiatives, institutional frameworks, and stakeholder collaborations. The findings highlight the potential for SSA to create a more forgiving and resilient transportation system, offering valuable guidance for policy decisions, future research, and interventions aimed at promoting safer road environments. SSA's comprehensive strategy for Safe Road Users encompasses considerations of road system design, behavior modification, and tailored measures for vulnerable users, showcasing its versatility in addressing diverse challenges. In the realm of Safe Vehicles, SSA actively involves manufacturers in a cycle of continuous improvement, rigorous testing, and collaborative efforts to establish new safety regulations. The emphasis on managing Safe Speeds, aligning with human parameters, and involving communities reflects SSA's adaptable nature and provides insights for establishing context-specific speed limits. SSA contributes significantly to Safe Roads through its implementation of innovative countermeasures, forgiving road designs, and the integration of emerging disciplines, resulting in a notable reduction in fatalities and injuries. In the domain of Post-Crash Care, SSA's integrated perspective fosters collaboration among emergency services, medical professionals, and the justice system. It addresses challenges through standardized approaches and information sharing, ensuring a comprehensive and unified approach to road safety. This review contributes to the ongoing efforts to prioritize safety and transform the transportation landscape on a global scale.
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http://dx.doi.org/10.1016/j.aap.2024.107518 | DOI Listing |
Cleft Palate Craniofac J
September 2025
Otorhinolaryngology-Head and Neck Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
ObjectiveTo compare between L pharyngeal flap alone and combined L pharyngeal flap with phenytoin for repair of palatal fistula and velopharyngeal insufficiency (VPI).MethodsTwenty patients with soft palate fistula and persistent VPI who were divided into two groups. In the first group, superiorly based L pharyngeal flap was harvested from the oropharynx and inserted into the soft palate to close the fistula after fistula trimming.
View Article and Find Full Text PDFJ Alzheimers Dis
September 2025
Paula Costa-Urrutia Medical Affairs, Terumo BCT, Edificio Think MVD, Montevideo, Uruguay.
BackgroundTherapeutic plasma exchange (TPE) with albumin replacement has emerged as a potential treatment for Alzheimer's disease (AD). The AMBAR trial showed that TPE could slow cognitive and functional decline, along with changes in core and inflammatory biomarkers in cerebrospinal fluid.ObjectiveTo evaluate the safety and effectiveness of TPE in a real-world setting in Argentina.
View Article and Find Full Text PDFJAMA
September 2025
Section of Urologic Oncology, Department of Urology, Michigan Medicine, Ann Arbor.
Surg Endosc
September 2025
Department of Surgery, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Background: Endoscopic vacuum therapy (EVT) has been established as a safe and effective treatment for anastomotic leakage. While rare, major aortic hemorrhage has been reported as a severe complication potentially associated with EVT. However, significant hemorrhages have also been observed in patients with transmural defects in the upper gastrointestinal tract, without the use of EVT.
View Article and Find Full Text PDFGen Thorac Cardiovasc Surg
September 2025
Department of General Thoracic Surgery, Seirei Hamamatsu General Hospital, 2-12-12, Hamamatsu, Shizuoka, 430-8558, Japan.
Thoracoscopic surgery for stage III acute empyema is often limited by poor visualization and anatomical complexity. We developed a standardized, minimally invasive approach using a variable-view rigid endoscope and fixed port placement, regardless of disease extent or patient physique. The variable-view endoscope enabled a wide, adjustable field of view without moving the camera shaft, allowing safe access even in the confined thoracic space.
View Article and Find Full Text PDF