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This study examined the utility of the combined use of transabdominal ultrasonography (TUS) and fecal immunochemical testing (FIT) to detect mucosal inflammation, vis-a-vis the Mayo endoscopic subscore (MES), in ulcerative colitis (UC). Sixty-three UC patients who underwent TUS and FIT were retrospectively enrolled. For TUS, the colon was divided into five segments, and the bowel wall thickness was measured and evaluated. The accuracy of FIT (> 100 ng/ml) in detecting mucosal inflammation (MES>0) was 0.93, whereas that of TUS (BWT>2 mm) in each segment was 0.84-0.97. The combined use of TUS and FIT may be helpful in noninvasive treatment strategies.
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http://dx.doi.org/10.18926/AMO/66674 | DOI Listing |
JAMA Netw Open
September 2025
Oncostat U1018, Institut National de la Santé et de la Recherche Médicale (INSERM), Ligue Contre le Cancer, Paris-Saclay University, Villejuif, France.
Importance: Antibiotics, steroids, and proton pump inhibitors (PPIs) are suspected to decrease the efficacy of immunotherapy.
Objective: To explore the association of comedications with overall survival (OS) in patients with advanced non-small-cell lung cancer (NSCLC).
Design, Setting, And Participants: This nationwide retrospective cohort study used target trial emulations of patients newly diagnosed with NSCLC from January 2015 to December 2022, identified from the French national health care database.
Mol Biol Rep
September 2025
School of Arts and Sciences, Department of Natural and Applied Sciences, The American University of Iraq-Baghdad, Baghdad, Iraq.
The COVID-19 pandemic, caused by the continuously evolving SARS-CoV-2 virus, has presented persistent global health challenges. As novel variants emerge, many with enhanced transmissibility and immune evasion capabilities, concerns have intensified regarding the efficacy of existing vaccines and therapeutics. This review provides a comprehensive overview of the current landscape of COVID-19 vaccination, including the development and performance of monovalent and bivalent boosters, and examines their effectiveness against newly emerging variants of interest (VOIs) and variants under monitoring (VUMs), such as JN.
View Article and Find Full Text PDFJ Pathol
September 2025
The North of England Bone and Soft Tissue Tumour Service, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Indocyanine green (ICG) is a well-established near-infrared dye which has been used clinically for several decades. Recently, it has been utilised for fluorescence-guided surgery in a range of solid cancer types, including sarcoma, with the aim of reducing the positive margin rate. The increased uptake and retention of ICG within tumours, compared with normal tissue, gives surgeons a visual reference to aid resection when viewed through a near-infrared camera.
View Article and Find Full Text PDFBull Math Biol
September 2025
Department of Mathematics and Faculty of Medicine, The University of Ottawa, Ottawa, ON, K1N 6N5, Canada.
Host defense and pathogen virulence interact and mutually shape each other's evolution. Host-pathogen co-evolutionary outcomes have potentially significant impacts on population dynamics and vice versa. To investigate host-pathogen interactions and explore the impact of micro-level co-evolutionary outcomes on macro-level epidemics, we develop a co-evolutionary model with a combined host-defense strategy.
View Article and Find Full Text PDFAbdom Radiol (NY)
September 2025
Peking University First Hospital, Beijing, China.
Purpose: To evaluate the feasibility and clinical utility of non-contrast magnetic resonance angiography (NC-MRA) using a modified balanced steady-state free precession (b-SSFP) technique combined with arterial spin labeling (ASL) for post-embolotherapy follow-up of renal artery aneurysms (RAAs), with digital subtraction angiography (DSA) as the reference standard.
Method: A total of 57 patients with RAAs underwent embolotherapy between June 2013 and July 2024. Among them, 15 RAAs from 14 patients underwent post-embolization surveillance with the NC-MRA and DSA.