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In this 2-institution feasibility pilot, oncology fellows used and updated freely available web-based learning tools (scaffolds) in a constructivist fashion.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10924254 | PMC |
http://dx.doi.org/10.2196/52501 | DOI Listing |
Mol Divers
September 2025
Key Laboratory of Tropical Biological Resources of Ministry of Education and Hainan Engineering Research Center for Drug Screening and Evaluation, School of Pharmaceutical Sciences, Hainan University, Haikou, 570228, China.
Lead optimization is a crucial step in drug design. Generative AI-driven molecular modification has emerged as a powerful strategy to accelerate lead optimization by efficiently exploring chemical space and enhancing key drug-like properties. However, current AI tools primarily focus on de novo scaffold design rather than targeted modifications of validated lead compounds, limiting their practical utility in medicinal chemistry.
View Article and Find Full Text PDFJ Microbiol Biol Educ
August 2025
University of New Hampshire Manchester, Manchester, New Hampshire, USA.
Integrating primary scientific literature into Science, Technology, Engineering, and Mathematics (STEM) curricula enhances critical thinking, scientific literacy, and communication skills but presents challenges due to complex terminology and data interpretation barriers. To address these challenges, a scaffolded journal club approach was implemented in a Cancer Biology course. The course utilized Hypothes.
View Article and Find Full Text PDFACS Omega
April 2025
Department of Pharmacy, Universita degli Studi di Salerno, Via Giovanni Paolo II 132, Fisciano 84084, Campania, Italy.
Drug-induced liver injury (DILI) represents a critical safety concern for drug development, regulatory oversight, and clinical practice, with substantial economic and public health implications. While predicting DILI risk in humans has garnered significant attention, the associated chemical space has remained insufficiently explored. This study addresses this gap through a comprehensive computational approach, leveraging machine learning (ML) to investigate structural determinants of DILI risk systematically.
View Article and Find Full Text PDFBraz J Microbiol
March 2025
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, 05508-900, Brazil.
Despite meticulous precautions, contamination of genomic DNA samples is not uncommon, which can significantly compromise the analysis of microorganisms' whole-genome sequencing data, thus affecting all subsequent analyses. Thanks to advancements in software and bioinformatics techniques, it is now possible to address this issue and prevent the loss of the entire dataset obtained in a contaminated whole-genome sequencing, where the DNA of another bacterium is present. In this study, it was observed that the sequencing reads from Streptomyces sp.
View Article and Find Full Text PDFBMC Med
November 2024
Australian Research Council (ARC) Training Centre for Multiscale 3D Imaging, Modelling, and Manufacturing (M3D Innovation), Queensland University of Technology, Brisbane, QLD, 4000, Australia.
Background: With over 2 million grafts performed annually, bone ranks second only to blood in the frequency of transplants. This high demand is primarily driven by the persistent challenges posed by bone defects, particularly following trauma or surgical interventions such as tumour excision. The demand for effective and efficient treatments has increased exponentially in the twenty-first century.
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