CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health.

Circ Res

Division of Molecular Cardiovascular Biology, The Heart Institute, Cincinnati Children's Hospital Medical Center, OH (M.L.K., C.A.M.).

Published: February 2024


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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10871552PMC
http://dx.doi.org/10.1161/CIRCRESAHA.124.324166DOI Listing

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LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2.

Circ Res

February 2024

Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College (X.N., J.F., B.D., Z.W., H.L., C.C., D.W.W.), Huazhong University of Science and Technology, Wuhan, China.

Background: Human cardiac long noncoding RNA (lncRNA) profiles in patients with dilated cardiomyopathy (DCM) were previously analyzed, and the long noncoding RNA CHKB (choline kinase beta) divergent transcript (CHKB-DT) levels were found to be mostly downregulated in the heart. In this study, the function of CHKB-DT in DCM was determined.

Methods: Long noncoding RNA expression levels in the human heart tissues were measured via quantitative reverse transcription-polymerase chain reaction and in situ hybridization assays.

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