Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Antibiotic resistance is a significant global public health concern. Uropathogenic Escherichia coli sequence type (ST)131, a widely prevalent multidrug-resistant clone, is frequently associated with bacteraemia. This study investigates third-generation cephalosporin resistance in bloodstream infections caused by E. coli ST131. From 2013-2014 blood culture surveillance in Wales, 142 E. coli ST131 genomes were studied alongside global data. All three major ST131 clades were represented across Wales, with clade C/H30 predominant (n = 102/142, 71.8%). Consistent with global findings, Welsh strains of clade C/H30 contain β-lactamase genes from the bla group (n = 65/102, 63.7%), which confer resistance to third-generation cephalosporins. Most Welsh clade C/H30 genomes belonged to sub-clade C2/H30Rx (58.3%). A Wales-specific sub-lineage, named GB-WLS.C2, diverged around 1996-2000. An introduction to North Wales around 2002 led to a localised cluster by 2009, depicting limited genomic diversity within North Wales. This investigation emphasises the value of genomic epidemiology, allowing the detection of genetically similar strains in local areas, enabling targeted and timely public health interventions.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10866875 | PMC |
| http://dx.doi.org/10.1038/s41467-024-45608-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Virulence factors and outcomes in bacteremia caused by extended-spectrum β-lactamase-producing uropathogenic Escherichia coli ST131-H30Rx in a Swedish county.
BMC Infect Dis
September 2025
Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Background: Escherichia coli ST131 and clade H30Rx are the most prevalent extended-spectrum β-lactamase-producing E. coli (ESBL-EC) causing bacteremia and urinary tract infections globally and in Sweden. Previous studies have linked ST131-H30Rx with septic shock and mortality, as well as prolonged carriage.
View Article and Find Full Text PDFGenomic diversity of uropathogenic Escherichia coli in clinical isolates from six latin american countries, 2018-2023.
Rev Peru Med Exp Salud Publica
August 2025
Universidad Peruana Cayetano Heredia, Laboratorio de Genómica Microbiana, Lima, Perú.
Background: Motivation for the study. To contribute to the genomic surveillance of UPEC in clinical samples from Latin America, in response to the growing public health problem represented by UTIs and their resistance to antimicrobials. Main findings.
View Article and Find Full Text PDFGenomic Epidemiology of ESBL- and Carbapenemase-Producing Enterobacterales in a Spanish Hospital: Exploring the Clinical-Environmental Interface.
Microorganisms
August 2025
Area of Biochemistry and Molecular Biology, One Health-UR Research Group, Faculty of Science and Technology, Universidad de La Rioja, Madre de Dios 53, 26006 Logroño, Spain.
Antimicrobial resistance (AMR), particularly due to extended-spectrum β-lactamases (ESBLs) and carbapenemases (CPs), poses a critical threat to global health. This study aimed to characterize the molecular epidemiology, resistance profiles, and genomic features of ESBL- and CP-producing and (ESBL/CP-Ec/Kp) isolates from a Spanish hospital (2020-2024) and explore links to environmental reservoirs like white storks foraging at a nearby landfill. A total of 121 clinical Ec/Kp isolates (55 ESBL-Ec, 1 CP-Ec, 35 ESBL-Kp, 17 CP-Kp, 13 ESBL+CP-Kp) underwent phenotypic testing, PCR, and whole-genome sequencing (WGS).
View Article and Find Full Text PDFEnvironmental Dispersion of Multiresistant in Aquatic Ecosystems in an Area of Spain with a High Density of Pig Farming.
Antibiotics (Basel)
July 2025
Fundació Lluita Contra les Infeccions, Infectious Diseases Department, Hospital Universitari Germans Trias i Pujol, 08916 Badalona, Spain.
: This study aimed to (a) assess the prevalence of multidrug-resistant (MDR) in the waters of two rivers and wastewater treatment plants (WWTPs) in a region of Catalonia, Spain; (b) genetically characterize the MDR strains; and (c) compare extended-spectrum β-lactamase (ESBL)-producing isolates from environmental and human sources. : A total of 62 samples were collected from the influent and effluent of 31 WWTPs and 29 river water samples from 11 sites. Simultaneously, 382 hospitalized patients were screened for MDR using rectal swabs.
View Article and Find Full Text PDFCharacterization of ertapenem-resistant Enterobacterales in Canadian hospitals: 17 years of the CANWARD study (2007-23).
J Antimicrob Chemother
August 2025
Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Room 543-745 Bannatyne Avenue, Winnipeg Manitoba R3E 0J9, Canada.
Objectives: To review phenotypic and genotypic characteristics of ertapenem-resistant Enterobacterales isolates identified by the CANWARD study from 2007 to 2023.
Methods: Bacterial isolates were collected as part of the CANWARD surveillance study from 2007 to 2023. CLSI M7 broth microdilution antimicrobial susceptibility testing (12th edition, 2024) was performed.