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Background: The COVID-19 pandemic has required evidence to be made available more rapidly than usual, in order to meet the needs of decision makers in a timely manner. These exceptional circumstances have caused significant challenges for organizations and teams responsible for evidence synthesis. They had to adapt to provide rapid responses to support decision-making. This study aimed to document (1) the challenges and adaptations made to produce rapid responses during the pandemic, (2) their perceived usefulness, reported use and factors influencing their use and (3) the methodological adaptations made to produce rapid responses.
Methods: A qualitative study was conducted in 2021 with eight organizations in the health and social services system in Quebec (Canada), including three institutes with a provincial mandate. Data collection included focus groups (n = 9 groups in 8 organizations with 64 participants), interviews with decision makers (n = 12), and a document analysis of COVID-19 rapid responses (n = 128). A thematic analysis of qualitative data (objectives 1 and 2) and a descriptive analysis of documents (objective 3) were conducted.
Results: The results highlight the teams and organizations' agility to deal with the many challenges encountered during the pandemic (e.g., increased their workloads, adoption of new technological tools or work processes, improved collaboration, development of scientific monitoring, adaptation of evidence synthesis methodologies and products). The challenge of balancing rigor and speed was reported by teams and organizations. When available at the right time, rapid responses have been reported as a useful tool for informing or justifying decisions in a context of uncertainty. Several factors that may influence their use were identified (e.g., clearly identify needs, interactions with producers, perceived rigor and credibility, precise and feasible recommendations). Certain trends in the methodological approaches used to speed up the evidence synthesis process were identified.
Conclusions: This study documented rapid responses producers' experiences during the COVID-19 pandemic in Quebec, and decision makers who requested, consulted, or used these products. Potential areas of improvements are identified such as reinforce coordination, improve communication loops, clarify guidelines or methodological benchmarks, and enhance utility of rapid response products for decision makers.
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http://dx.doi.org/10.1186/s12961-024-01105-x | DOI Listing |
Proc Natl Acad Sci U S A
September 2025
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN 37240.
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid antidepressant effects by blocking spontaneous N-Methyl-D-Aspartate (NMDA) receptor signaling, which lifts the suppression of protein synthesis and triggers homeostatic synaptic plasticity. Here, we identify a parallel signaling pathway involving metabotropic glutamate receptor 5 (mGluR5) that promotes rapid antidepressant-like effects.
View Article and Find Full Text PDFJ Appl Genet
September 2025
Faculty of Natural Sciences, Institute of Biology, Biotechnology and Environmental Protection, University of Silesia in Katowice, 40-032, Katowice, Poland.
Mechanical wounding triggers rapid transcriptional and hormonal reprogramming in plants, primarily driven by jasmonate (JA) signalling. While the role of JA, ethylene, and salicylic acid in wound responses is well characterised, the contribution of strigolactones (SLs) remains largely unexplored. Here, for the first time, it was shown that SLs modulate wound-induced transcriptional dynamics in Arabidopsis thaliana.
View Article and Find Full Text PDFAnal Bioanal Chem
September 2025
Hebei Key Laboratory of Public Health Safety, Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, College of Public Health, College of Chemistry and Materials Science, Hebei University, Baoding, 071002, China.
This work presents the development of a highly sensitive, selective, and efficient aptamer-based fluorescent sensor for detecting cortisol in human urine. Carbon quantum dots-nucleic acid aptamer (CQDs-Apt) synthesized with excellent photoluminescent properties and stability, were selected as the fluorescent probe. In the presence of MoS-NSs, CQDs-Apt adsorbed onto the surface of MoS-NSs via electrostatic and π-π interactions, leading to strong and rapid fluorescence quenching due to static quenching mechanism between them.
View Article and Find Full Text PDFJ Toxicol Environ Health A
September 2025
Department of Ecology and Conservation, Natural Sciences Institute, Federal University of Lavras, Lavras, MG, Brazil.
Flumioxazin-based herbicides are frequently used in agriculture to control broadleaf weeds attributed to their high efficacy, rapid action, and residual soil activity, making these compounds a preferred choice over other herbicides in pre-emergence weed control. Due to their beneficial properties, use of these herbicides has significantly increased in recent years, raising concerns regarding potential environmental risks. This study aimed to examine the effects of a commercial flumioxazin-based formulation on different plant models.
View Article and Find Full Text PDFLab Chip
September 2025
Institute of Integrated Research, Institute of Science Tokyo, R2-9, 4259 Nagatsuta-cho, Midoriku, Yokohama, Kanagawa 226-8501, Japan.
Tunability in isolating target cells of varying sizes from complex heterogeneous samples is essential for biomedical research and diagnostics. However, conventional deterministic lateral displacement (DLD) systems lack flexibility due to their fixed critical diameters (). Here, we present a thermo-responsive DLD micropillar array that enables tunable cell separation by dynamically modulating through temperature control.
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