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Monomorphic epitheliotropic intestinal T-cell lymphoma(MEITL)is very rare and aggressive subtype of lymphoma with poor prognosis. A 60-year-old man complaining of abdominal pain was underwent partial resection of the jejunum for panperitonitis with a small intestinal perforation. The histopathological and immunohistochemical findings led to the diagnosis of MEITL. Postoperative course was uneventful. One month after the operation, the patient was scheduled for 6 courses of CHOP regimens. He presented with bowel obstruction twice during the 3 courses of CHOP. As the recurrence of MEITL could not be ruled out, diagnostic laparoscopy was performed. Laparoscopic findings revealed no recurrence and adhesive small bowel obstruction. The patient was followed closely without treatment after 6 courses of CHOP. The patient has been alive without recurrence 18 months after the resection. We reported a case of monomorphic epithelial intestinal T- cell lymphoma causing jejunal perforation.
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Ann Med Surg (Lond)
August 2025
Department of Pediatric Hematology and Oncology, University of Health Sciences, Adana Faculty of Medicine, Adana City Education and Research Hospital, Adana, Turkey.
Introduction And Importance: T-lymphoblastic lymphoma (T-LBL) is a rare and aggressive subtype of precursor T-cell lymphomas, often presenting with lymph node, bone marrow, and mediastinal involvement. Cutaneous involvement is uncommon but associated with a poor prognosis.
Case Presentation: We report the case of a 17-year-old female with relapsed T-LBL presenting with bilateral breast masses, confirmed by biopsy and immunohistochemistry.
AJNR Am J Neuroradiol
August 2025
From the Department of Radiology (J.I., G.C.Y.C., E.J.E., A.K.-G., M.R.), Weill Cornell Medicine, New York, NY, USA; the Department of Radiology (A.M.F.), Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lenox Hill Hospital, New York, NY, USA; the Department of Radiology (M.W., A.K
Background: Molecular imaging, particularly positron emission tomography (PET), has significantly advanced the diagnosis and management of disease by visualizing biological processes at a cellular and molecular level. PET imaging of the brain, spine, and head/neck, summarized under the umbrella term Neuro-PET, enables noninvasive diagnosis and monitoring of diseases such as dementia, epilepsy, cancer, movement, or autoimmune disorders. The rising prevalence of these conditions, as well as new treatment options necessitating response assessment, are expected to escalate Neuro-PET imaging volumes, with projections for a significant increase in the need for specialized imaging services.
View Article and Find Full Text PDFBackground: Dysregulation of apoptosis in diffuse B-large cell lymphoma (DLBCL) contributes to increased tumor proliferation, as well as the formation of resistance to treatment. One of the most relevant areas of molecular research is the study of the mechanisms of programmed cell death - apoptosis. The AIF (Apoptosis Inducing Factor) protein participates in the regulation of the caspase-independent pathway of cell death and is a potential predictor of the course of DLBCL.
View Article and Find Full Text PDFBrain Sci
June 2025
Grupo de Investigación en Enfermedad de Parkinson y Otros Trastornos del Movimiento, INIBIC (Instituto de Investigación Biomédica de A Coruña), 15006 A Coruña, Spain.
Safinamide can improve the non-motor symptoms (NMSs) and quality of life (QoL) in patients with Parkinson's disease (PD). In this post hoc analysis of the SAFINONMOTOR study, we analyzed the effect of safinamide on NMSs and QoL according to age, sex, disease duration (DD), and levodopa equivalent daily dose (LEDD). The change from baseline to the end of the observational period (6 months) in the Non-Motor Symptoms Scale (NMSS) and the 39-item Parkinson's Disease Quality of Life Questionnaire (PDQ-39) was analyzed in subgroups according to sex (male vs.
View Article and Find Full Text PDFBMC Pulm Med
July 2025
University of Maryland School of Medicine, Baltimore, MD, USA.
Background: Rituximab is a chimeric human-mouse immunoglobulin monoclonal antibody with high affinity for CD20 surface antigens expressed by pre-B and B cells that is commonly used as the mainstay for the treatment of B cell non-Hodgkin's lymphomas, including diffuse large B-cell lymphoma (DLBCL). As the drug has become more widely used, rituximab associated Interstitial Lung disease (RTX-ILD) is being recognized as potential complication (Non-infectious pulmonary toxicity of rituximab: a systematic review| Rheumatology| Oxford Academic).
Case Report: We discuss a 73-year-old woman with newly diagnosed DLBCL who underwent chemotherapy and immunotherapy with rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine sulphate, and prednisone (R-CHOP).