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The Santa Barbara Basin is an extraordinary archive of environmental and ecological change, where varved sediments preserve microfossils that provide an annual to decadal record of the dynamics of surrounding ecosystems. Of the microfossils preserved in these sediments, benthic foraminifera are the most abundant seafloor-dwelling organisms. While they have been extensively utilized for geochemical and paleoceanographic work, studies of their morphology are lacking. Here we use a high-throughput imaging method (AutoMorph) designed to extract 2D data from photographic images of fossils to produce a large image and 2D shape dataset of recent benthic foraminifera from two core records sampled from the center of the Santa Barbara Basin that span an ~800-year-long interval during the Common Era (1249-2008 CE). Information on more than 36,000 objects is included, of which more than 22,000 are complete or partially-damaged benthic foraminifera. The dataset also includes other biogenic microfossils including ostracods, pteropods, diatoms, radiolarians, fish teeth, and shark dermal denticles. We describe our sample preparation, imaging, and identification techniques, and outline potential data uses.
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http://dx.doi.org/10.1038/s41597-024-02934-9 | DOI Listing |
Mol Ther Nucleic Acids
September 2025
PhyMedExp, University of Montpellier, INSERM, CNRS, Montpellier, France.
Nucleic acid molecules are emerging as potential therapeutic tools, as evidenced by the transfection of small interfering RNA (siRNA) molecules in therapeutic applications and messenger RNAs in immunotherapeutic vaccination. In most cases, these nucleic acids are conditioned as lipid nanoparticles made with different lipid moieties to promote their intracellular delivery. Over the past few years, we have documented the delivery of siRNAs using a single short (15 amino acids) peptide called WRAP5, which follows an extremely simplified formulation phase that enables the formation of nanoparticles with a diameter of 60-80 nm.
View Article and Find Full Text PDFJ Biomed Sci
July 2025
PHYMEDEXP, University of Montpellier, INSERM, CNRS, Montpellier, France.
Background: Clinical research has identified stomach dysmotility as a common feature of obesity. However, the specific mechanisms driving gastric emptying dysfunction in patients with obesity remain largely unknown. In this study, we investigated potential mechanisms by focusing on the homeostasis of gastric smooth muscle.
View Article and Find Full Text PDFFront Psychol
June 2025
Teachers College Columbia University, New York, NY, United States.
Purpose: Psychological trauma can lead to PTSD which is associated with numerous negative health outcomes. Exercise has beneficial effects on PTSD; however, the amount of exercise associated with these benefits remains unknown. To examine self-reported exercise-related differences in PTSD symptom severity, psychological distress, pain, and sleep quality in a national sample of trauma-exposed adults.
View Article and Find Full Text PDFBioconjug Chem
June 2025
PhyMedExp, University of Montpellier, INSERM U1046, CNRS UMR 9214371, Avenue du Doyen G. Giraud, CHU Arnaud de Villeneuve, Bâtiment Crastes de Paulet, 34295 Montpellier, Cedesx 5, France.
Cancer remains the leading cause of death, with chemotherapy, radiotherapy, and surgical resection being the primary treatment methods. However, chemotherapy's side effects, surgical limitations, and drug resistance present significant challenges. Small interfering RNA (siRNA) has emerged as a promising tool in cancer therapy due to its ability to silence disease-related genes selectively.
View Article and Find Full Text PDFPeople with HIV (PWH) smoke cigarettes 2-3 times more and are 3 times more likely to have clinical depression relative to the general population. Physical activity (PA) can aid in smoking cessation and reduce depression in the general population; the role of PA for smoking cessation among PWH is unknown. Data collected between October 2021-September 2022 from the Multicenter AIDS Cohort Study (MACS)/Women Interagency HIV Study (WIHS) Combined Cohort Study (MWCCS) were analyzed using logistic regression and structural equation modeling to examine associations between cigarette smoking, PA and depression.
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