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Aims: Expert knowledge to correctly interpret electrocardiograms (ECGs) is not always readily available. An artificial intelligence (AI)-based triage algorithm (DELTAnet), able to support physicians in ECG prioritization, could help reduce current logistic burden of overreading ECGs and improve time to treatment for acute and life-threatening disorders. However, the effect of clinical implementation of such AI algorithms is rarely investigated.
Methods And Results: Adult patients at non-cardiology departments who underwent ECG testing as a part of routine clinical care were included in this prospective cohort study. DELTAnet was used to classify 12-lead ECGs into one of the following triage classes: normal, abnormal not acute, subacute, and acute. Performance was compared with triage classes based on the final clinical diagnosis. Moreover, the associations between predicted classes and clinical outcomes were investigated. A total of 1061 patients and ECGs were included. Performance was good with a mean concordance statistic of 0.96 (95% confidence interval 0.95-0.97) when comparing DELTAnet with the clinical triage classes. Moreover, zero ECGs that required a change in policy or referral to the cardiologist were missed and there was a limited number of cases predicted as acute that did not require follow-up (2.6%).
Conclusion: This study is the first to prospectively investigate the impact of clinical implementation of an ECG-based AI triage algorithm. It shows that DELTAnet is efficacious and safe to be used in clinical practice for triage of 12-lead ECGs in non-cardiology hospital departments.
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http://dx.doi.org/10.1093/ehjdh/ztad070 | DOI Listing |
PLoS One
September 2025
School of Pharmacy, School of Health Sciences, College of Medicine and Health, University of Birmingham, Edgbaston, United Kingdom.
Aims: The aim of this research is to explore the suspected adverse drug reactions (ADRs) of perfluorinated medicines to determine whether side effects commonly associated with per- and poly-fluoroalkyl substances (PFAS) exposure were correlated to the type or number of fluorine atoms in these medications.
Methods: Thirteen fluorinated drugs and six non-fluorinated (or low fluorinated) comparators were selected after systematic triage. The reported ADR data from the Medicines and Healthcare Products Regulatory Agency's (MHRA) Yellow Card, and prescribing data from the OpenPrescribing database and the National Health Service Business Service Authority (NHSBSA) over a 5-year period were curated.
Ann Thorac Cardiovasc Surg
August 2025
Department of Cardiovascular Surgery, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Purpose: Rapid risk stratification is crucial in patients with acute type A aortic dissection (ATAAD), particularly those presenting with circulatory collapse or malperfusion. This study investigated whether preoperative blood lactate levels could predict surgical outcomes.
Methods: A retrospective analysis was conducted on 166 patients who underwent emergency surgery for ATAAD between 2014 and 2022.
Int J Mol Sci
August 2025
Experimental Physiology Laboratory, Superior Institute of Biomedical Sciences, State University of Ceará, Fortaleza 60714-903, CE, Brazil.
Monoterpenoids are a structurally diverse class of natural products with a long-standing history of therapeutic use. Despite their promising bioactivities, their clinical development has been limited by dose-dependent toxicities, poor pharmacokinetics, and suboptimal drug-like properties. In this work, a comprehensive in silico pipeline was employed to evaluate 1175 monoterpenoid compounds retrieved from ChEBI, aiming to identify structurally diverse candidates that possess favorable drug-like characteristics.
View Article and Find Full Text PDFPharmacy (Basel)
July 2025
Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
Hemorrhoidal disease remains a prevalent yet often overlooked condition, affecting millions worldwide and imposing a substantial healthcare burden. Despite the availability of multiple treatment options, gaps persist in patient education, early symptom recognition, and optimal treatment selection. Recent advancements are evolving the pharmacist's role in hemorrhoid management beyond traditional over-the-counter (OTC) and prescription approaches.
View Article and Find Full Text PDFJ Imaging
August 2025
Department of Computer Science, American International University-Bangladesh, Dhaka 1229, Bangladesh.
Timely, balanced, and transparent detection of retinal diseases is essential to avert irreversible vision loss; however, current deep learning screeners are hampered by class imbalance, large models, and opaque reasoning. This paper presents a lightweight attention-augmented convolutional neural network (CNN) that addresses all three barriers. The network combines depthwise separable convolutions, squeeze-and-excitation, and global-context attention, and it incorporates gradient-based class activation mapping (Grad-CAM) and Grad-CAM++ to ensure that every decision is accompanied by pixel-level evidence.
View Article and Find Full Text PDF