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Shiraz disease (SD) is one of the most destructive viral diseases of grapevines in Australia and is known to cause significant economic loss to local growers. Grapevine virus A (GVA) was reported to be the key pathogen associated with this disease. This study aimed to better understand the diversity of GVA variants both within and between individual SD and grapevine leafroll disease (LRD) affected grapevines located at vineyards in South Australia. Amplicon high throughput sequencing (Amplicon-HTS) combined with median-joining networks (MJNs) was used to analyze the variability in specific gene regions of GVA variants. Several GVA variant groups contain samples from both vineyards studied, suggesting that these GVA variants were from a common origin. Variant groups analyzed by MJNs using the overall data set denote that there may be a possible relationship between variant groups of GVA and the geographical location of the grapevines.
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http://dx.doi.org/10.3390/v16010042 | DOI Listing |
An Bras Dermatol
August 2025
Dermatology Department, Complejo Hospitalario Universitario A Coruña, A Coruña, Spain.
Mol Diagn Ther
July 2025
Cellular, Molecular and Genomics Biomedicine Group, La Fe Health Research Institute, Valencia, Spain.
Background And Objective: Primary ciliary dyskinesia (PCD) is a rare genetic condition characterised by abnormal ciliary motility, primarily affecting the respiratory tract. Despite its clinical significance, there is currently no gold standard for PCD diagnosis. This study aims to address this diagnostic challenge by evaluating a comprehensive approach in a large cohort of patients with suspected PCD.
View Article and Find Full Text PDFPhysiol Rev
October 2025
Department of Pharmacology, Faculty of Medicine, University of Valencia, Valencia, Spain.
Mucins are large glycoproteins that form the primary structural component of mucus and can be classified into secreted and transmembrane types. Of the 22 identified mucin genes, 12 encode transmembrane mucins, which play crucial roles in maintaining epithelial barrier integrity, modulating cell signaling, and innate immune responses to pathogens. Transmembrane mucins are expressed in epithelial cells, inflammatory cells, endothelial cells, and fibroblasts, influencing diverse cellular processes.
View Article and Find Full Text PDFPediatr Rheumatol Online J
December 2024
Translational Genetics Research Group, La Fe Health Research Institute (IIS La Fe), Avenida Fernando Abril Martorell nº 106 Tower A, 7th Floor, Valencia, Spain.
Background: Aicardi-Goutières Syndrome is a monogenic type 1 interferonopathy with infantile onset, characterized by a variable degree of neurological damage. Approximately 7% of Aicardi-Goutières Syndrome cases are caused by pathogenic variants in the ADAR gene and are classified as Aicardi-Goutières Syndrome type 6. Here, we present a new homozygous pathogenic variant in the ADAR gene.
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