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http://dx.doi.org/10.1111/jocd.16194 | DOI Listing |
Oral Oncol
September 2025
Department of Dermatology, Saveetha Medical College and Hospital (SMCH), Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Chennai 602105 Tamil Nadu, India. Electronic address:
The recent study by Alfertshofer et al., titled "Histopathological invasion patterns and prognosis in Oral Squamous Cell Carcinoma (OSCC): A retrospective analysis of 560 cases", presents a robust analysis of histopathological invasion markers specifically lymphatic (L1), perineural (Pn1), and vascular invasion (V1) and their prognostic relevance in OSCC. This commentary highlights the critical insights derived from their findings, particularly the independent prognostic value of L1 and Pn1 in relation to overall survival (OS), recurrence-free survival (RFS), and distant metastasis-free survival (DMFS).
View Article and Find Full Text PDFCancer Res
September 2025
Department of Translational Oncology, Genentech, Inc., South San Francisco, California.
Unlabelled: RIT1 is a RAS-family guanosine triphosphatase that is mutated in 2.4% and amplified in up to 14% of patients with lung adenocarcinoma. Yet the oncogenic potential of RIT1 in the lungs has not been fully established.
View Article and Find Full Text PDFObes Surg
July 2025
Northumbria Healthcare NHS Foundation Trust, North Shields, United Kingdom.
JAMA Dermatol
June 2025
The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York.
Importance: Metastatic cutaneous Crohn disease (MCD) is a rare condition for which there are currently no published diagnostic criteria. Formal MCD diagnostic criteria will expand clinical care and research by enabling future diagnostic code validation, crystallizing a more uniform disease entity for the purposes of translational research, and allowing the development of more formalized outcome measures aimed at treatment response.
Objective: To define a set of criteria for the diagnosis of MCD.