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We compared the effects of velocity-monitored resistance training with an intra-set velocity loss (i.e., the decrement in repetition velocity over the set) of 10 % vs. 20 % on strength-related outcomes in older adults. We randomly assigned eighteen older adults to a velocity loss group of 10 % (n = 10; 78 ± 12 years) or 20 % (n = 8; 73 ± 10 years) to perform a 10-week training program. The primary outcomes were the one-repetition maximum (1RM) and the average mean velocity against absolute loads associated with loads <60 % 1RM (MV) and ≥ 60 % 1RM (MV) in the leg and chest press exercises, assessed at pre-, mid- (week 5), and post-test. Secondary outcomes included handgrip strength, 1-kg medicine ball throw distance, 10-m walking time, and five-repetition sit-to-stand time. No differences between groups were found in any outcome at any time (p > 0.05). Both groups improved the 1RM leg press from pre- to mid- and post-test and the MV and MV from pre- to mid-test (p < 0.05). No group improved the 1RM chest press (p > 0.05), but both increased the MV from pre- to mid-test (p < 0.05). Furthermore, both groups improved the sit-to-stand time, while only the 20 % velocity loss group significantly improved handgrip strength and 10-m walking time (p < 0.05). The results showed that both velocity losses improved leg press strength and velocity, chest press velocity, and sit-to-stand time in older adults, although a 10 % velocity loss was more efficient as it required less volume (i.e., total repetitions) than 20 %. Nevertheless, the latter seems required to optimize handgrip strength and 10-m walking time in older people.
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http://dx.doi.org/10.1016/j.exger.2024.112361 | DOI Listing |
Front Physiol
August 2025
Facultad de Ciencias Biomédicas y de la Salud, Universidad Alfonso X el Sabio (UAX), Madrid, Spain.
Training structures such as every minute on minute (EMOM), as many repetitions as possible (AMRAP), and rounds for time (RFT) have gained popularity for improving sport performance and general health. However, limited research exists on how different relative loads affect neuromuscular and cardiorespiratory responses. This study aimed to compare acute effects on heart rate (HR), mean propulsive velocity (MPV), velocity loss, and pacing in participants performing AMRAP, EMOM, and RFT using the same absolute but varying relative loads.
View Article and Find Full Text PDFBiophys Rep (N Y)
September 2025
Cellular Signal Transduction in the Cardiovascular System COBRE, University of Nevada Reno, Reno, NV 89557; Department of Nutrition, University of Nevada Reno, Reno, NV 89557. Electronic address:
Skeletal muscle alpha actin (ACTA1) is important for muscle contraction and relaxation, with historical studies focused on ACTA1 mutations in muscle dysfunction. Proteomics reports have consistently observed that actin, including ACTA1, is acetylated at multiple lysine sites. However, few reports have studied the effects of actin acetylation on cellular function, and fewer have examined ACTA1 acetylation on skeletal muscle function.
View Article and Find Full Text PDFNeurology
October 2025
Department of Neurology, Leiden University Medical Center, the Netherlands.
Background And Objectives: Slow and highly variable disease progression in Becker muscular dystrophy (BMD) stresses the need to develop sensitive outcome measures for clinical trials. We evaluated responsiveness of different outcome measures in adult patients with BMD over 3 years and explored if the sensitivity of outcome measures can be increased by selecting on phenotype or genotype.
Methods: Genetically confirmed patients with BMD were recruited via the Dutch Dystrophinopathy Database.
Small
September 2025
Department of Chemical and Biological Engineering, University of Colorado Boulder, Boulder, CO, 80303, USA.
Adoptive cell transfers (ACTs) can interact specifically with inflamed tissues, but lack a mechanism for transport through viscous biological barriers such as mucus when administered locally. Further, maintaining cell function is challenging due to the loss of cellular phenotypes in diseased microenvironments. In this work, the use of magnetically controlled helical microrobots is examined to transport macrophages through physiologically representative mucus and maintain functional phenotypes through drug elution for improved cell delivery.
View Article and Find Full Text PDFEquine Vet J
September 2025
Department of Veterinary Medicine, University of Teramo, Teramo, Italy.
Background: Superficial digital flexor tendon (SDFT) injuries cause progressive loss of its mechanical properties. Two-dimensional shear wave elastography (2D-SWE) provides information about tissue stiffness.
Objective: To determine the feasibility, repeatability, and reproducibility of 2D-SWE of healthy and pathological forelimb SDFT.