98%
921
2 minutes
20
In the coming decades, as humanity aims to establish a presence on Mars, there is a growing significance in comprehending, monitoring, and controlling the diverse health challenges arising from space exploration. The extended exposure to microgravity during space missions leads to various physical alterations in astronauts, such as shifts in bodily fluids, reduced plasma volume, loss of bone density, muscle wasting, and cardiovascular deconditioning. These changes can ultimately lead to orthostatic intolerance, underscoring the increasing importance of addressing these health risks. Astronauts are exposed to cosmic radiation consisting of high-energy particles from various sources, including solar cosmic rays and galactic cosmic rays. These radiations can impact the electrical signals in the heart, potentially causing irregular heart rhythms. Understanding the risks to the heart and blood circulation brought on by exposure to space radiation and the overall stress of spaceflight is essential and this article reviews the cardiovascular effects of space travel on astronauts.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1097/CRD.0000000000000642 | DOI Listing |
Lancet Planet Health
September 2025
Department of Veterinary Tropical Diseases, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
Rift Valley fever (RVF), a zoonotic mosquito-borne viral disease with erratic occurrence and complex epidemiology, results in substantial costs to veterinary and public health and national economies. Since 1985, RVF virus (RVFV) epidemiology has focused on epidemics triggered by flood-induced emergence of transovarially infected mosquitoes, following an interepidemic period during which RVFV persists primarily in floodwater Aedes spp mosquito eggs, with potential for low-level interepidemic circulation. In this Personal View, we challenge this classic framework of RVFV epidemiology, presenting instead a spectrum of RVFV dynamics ranging from epidemic to hyperendemic.
View Article and Find Full Text PDFPLoS One
September 2025
College of Intelligent Science and Control Engineering, Jinling Institute of Technology, Nanjing, China.
Traffic congestion frequently occurs in the drop-off zones of large integrated passenger hubs, posing significant challenges to the efficient utilization of lane space. This study develops a First-In-First-Out (FIFO) taxi drop-off decision-making model, incorporating both static and dynamic Logit frameworks grounded in panel data analysis. The model accounts for heterogeneity across vehicles, temporal variations, and spatial factors influencing drop-off decisions.
View Article and Find Full Text PDFCell Stem Cell
September 2025
Sanford Stem Cell Institute Integrated Space Stem Cell Orbital Research (ISSCOR) Center, Division of Regenerative Medicine, Department of Medicine, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address:
Human hematopoietic stem and progenitor cell (HSPC) fitness declines following exposure to stressors that reduce survival, dormancy, telomere maintenance, and self-renewal, thereby accelerating aging. While previous National Aeronautics and Space Administration (NASA) research revealed immune dysfunction in low-earth orbit (LEO), the impact of spaceflight on human HSPC aging had not been studied. To study HSPC aging, our NASA-supported Integrated Space Stem Cell Orbital Research (ISSCOR) team developed bone marrow niche nanobioreactors with lentiviral bicistronic fluorescent, ubiquitination-based cell-cycle indicator (FUCCI2BL) reporter for real-time HSPC tracking in artificial intelligence (AI)-driven CubeLabs.
View Article and Find Full Text PDFWien Klin Wochenschr
September 2025
Department of Neurology, Medical University of Vienna, Vienna, Austria.
Background: Disease-modifying therapies with amyloid-antibodies will soon be available for patients with early Alzheimer's disease, which necessitates diagnostic and therapeutic resources in hospital and outpatient settings.
Methods: The Austrian Alzheimer Society developed an online questionnaire to survey Austrian hospital-based departments of neurology and psychiatry regarding resources for amyloid-antibody therapies.
Results: Between May and October 2023, 30 out of 41 neurology (73%) and 12 out of 33 psychiatry departments (36%) responded.
Front Microbiol
August 2025
Amentum Space Exploration Division, Huntsville, AL, United States.
Introduction: Microorganisms can have major impacts on the success of NASA's missions, including the integrity of materials, the protection of extraterrestrial environments, the reliability of scientific results, and maintenance of crew health. Robust cleaning and sterilization protocols for spacecraft and associated environments are currently in place in NASA facilities, but microbial contamination should be further controlled and its impact on NASA's missions and science must be minimized. To address this, air and surfaces across cleanrooms and uncontrolled spaces at the Marshall Space Flight Center were sampled and microbial burden and diversity were analyzed.
View Article and Find Full Text PDF