98%
921
2 minutes
20
Protein homeostasis, namely the balance between protein synthesis and degradation, must be finely controlled to ensure cell survival, notably through the ubiquitin-proteasome system (UPS). In all species, including plants, homeostasis is disrupted by biotic and abiotic stresses. A key player in the maintenance of protein balance, the protein CDC48, shows emerging functions in plants, particularly in response to biotic stress. In this review on CDC48 in plants, we detail its highly conserved structure, describe a gene expansion that is only present in Viridiplantae, discuss its various functions and regulations, and finally highlight its recruitment, still not clear, during the plant immune response.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.tplants.2023.12.013 | DOI Listing |
J Exp Bot
June 2025
Agroécologie, INRAE, Institut Agro, Université Bourgogne Europe, F-21000 DIJON, France.
The Unfolded Protein Response (UPR) is a signalling pathway activated when endoplasmic reticulum (ER) proteostasis is disturbed. We have investigated the contribution of UPR in Arabidopsis thaliana response to two necrotrophic fungi Botrytis cinerea and Alternaria brassicicola. We found out that the IRE1-bZIP60 branch of UPR was specifically activated upon infection with both pathogenic fungi, as evidenced by the production of the active bZIP60 transcription factor forms and the increased expression of UPR-responsive genes.
View Article and Find Full Text PDFPlant Biotechnol J
August 2025
Guangdong Provincial Key Laboratory of Plant Adaptation and Molecular Design, Innovative Center of Molecular Genetics and Evolution, School of Life Sciences, Guangzhou University, Guangzhou, China.
Roots act as the plants' primary determinants of the uptake of water and nutrients, while the root structure largely depends on the repeated formation of new lateral roots (LR). Lateral root primordium (LRP) formation defines the organization and function of LRs. Therefore, lateral root formation is quite related to proper LRP morphogenesis to a great extent.
View Article and Find Full Text PDFJ Exp Bot
April 2025
Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.
The inner nuclear membrane (INM) hosts a unique set of membrane proteins essential for nuclear functions. Proteolytic removal of mislocalized or defective membrane proteins is of critical importance for maintaining the homeostasis and integrity of the INM. Previous studies revealed that INM protein degradation depends on a specialized ubiquitin-proteasome system termed INM-Associated Degradation (INMAD) in plants, requiring the CDC48 complex and the 26S proteasome for membrane protein retrotranslocation and destruction, respectively.
View Article and Find Full Text PDFPlant Signal Behav
December 2025
Université Bourgogne Europe, Institut Agro Dijon, INRAE, UMR Agroécologie, Dijon, France.
Plants are continuously challenged by a myriad of pathogenic microorganisms, including bacteria, viruses, fungi and oomycetes, against which they must defend themselves. The protein Cell Division Cycle 48 (CDC48), a key player of ubiquitin-proteasome system which segregates and remodels ubiquitinated proteins for degradation, is known to be mobilized during plant immunity. Moreover, the characterization of the nuclear role of CDC48 is of interest, in particular its regulation in nuclear processes such as chromatin remodeling, DNA repair and gene expression.
View Article and Find Full Text PDFPlant J
February 2025
Comprehensive Experimental Center of Chinese Academy of Forestry in Yellow River Delta, Dongying, Shandong Province, 257000, People's Republic of China.
To explore the proteomic regulation that underlies the physiological, anatomical, and chemical characteristics of wood in acclimation to changing light and nitrogen (N), saplings of Populus × canescens were treated with control or high irradiance in combination with low, control or high N for 4 months. High irradiance led to elevated levels of starch, sucrose, glucose, and fructose, decreased concentrations of ammonium, nitrate, most amino acids and total N, wider xylem, more xylem cell layers, narrower vessel lumina, longer fiber cells, greater fiber wall thickness, and more cellulose and hemicellulose but less lignin deposition in poplar wood. Limiting N resulted in increased levels of starch and sucrose, reduced levels of glucose, fructose, ammonium, nitrate, amino acids and total N, narrower xylem, fewer xylem cell layers, reduced vessel lumen diameter, thicker fiber walls, and less cellulose and more hemicellulose and lignin accumulation, whereas high N had the opposite effects on poplar wood.
View Article and Find Full Text PDF