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http://dx.doi.org/10.1093/bjs/znad418 | DOI Listing |
JAMA Surg
July 2025
Colorectal Unit, General and Digestive Surgery Department, Bellvitge University Hospital, University of Barcelona and IDIBELL, Barcelona, Spain.
Importance: According to international guidelines, the standard treatment for stage T2-T3ab, N0, M0 rectal cancer is total mesorectal excision (TME), but it is associated with high morbidity and quality of life disorders.
Objective: To analyze locoregional recurrence (LR) after a follow-up of 2 years, applying a 1-sided noninferiority margin of 10%, and to assess distant recurrence (DR), overall survival (OS), and disease-free survival (DFS).
Design, Setting, And Participants: This was a multicenter, prospective, open-label, noninferiority, phase 3 randomized clinical trial comparing TME (TME group) with chemoradiotherapy followed by local excision with transanal endoscopic microsurgery (CRT-TEM group).
Eur J Surg Oncol
July 2025
Department of Colorectal Surgery, Ningbo No. 2 Hospital, No. 41 Northwest Street, Haishu District, Ningbo, 315010, Zhejiang Province, China. Electronic address:
Clinics (Sao Paulo)
April 2025
Changchun University of Chinese Medicine, Changchun, Jilin, PR China.
Surgery
July 2025
The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Suzhou, China. Electronic address:
Colorectal Dis
April 2024
Queen's University, Kingston, Ontario, Canada.