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http://dx.doi.org/10.1016/j.explore.2023.12.012 | DOI Listing |
Open Med (Wars)
August 2025
Department of Traditional Chinese Medicine, Shanghai Chongming District Hospital of Traditional Chinese and Western Medicine, Shanghai, 202153, China.
Background: Emerging evidence suggests that hemorrhoids are associated with cardiovascular disease (CVD). However, the causal associations between hemorrhoids and CVD remain elusive. This study aimed to investigate potential causal links between hemorrhoids and various heart conditions, including arrhythmia, heart failure, myocardial infarction, atrial fibrillation, and coronary artery disease.
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September 2025
Nursing, Good Samaritan University Hospital, West Islip, USA.
In the management of adults, troponins are routinely used to detect acute coronary syndrome and to predict increased risk of mortality. However, there is limited information available on the utility of troponin for risk assessment in children with chest pain. This study aimed to investigate whether elevated troponin in pediatric patients (0-21 years of age, as per guidelines during the sampling timeframe) presenting with chest pain has a role as a prognostic biomarker for myocardial dysfunction.
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August 2025
Internal Medicine, Majmaah University, Al Majma'ah, SAU.
Background: A relationship between obesity, as measured by body mass index (BMI), and multiple sclerosis (MS) has been reported in several observational studies. This study aimed to investigate the potential causal relationship between BMI and the risk of developing MS using a Mendelian randomization (MR) approach.
Materials And Methods: A two-sample MR analysis was performed using single nucleotide polymorphisms (SNPs) associated with the exposures - BMI and MS - sourced from publicly available genome-wide association studies (GWAS) at a genome-wide significance threshold of = 5 × 10.
NeuroRehabilitation
September 2025
Department of Rehabilitation and Australian Rehabilitation Research Centre, Royal Melbourne Hospital, Parkville, Victoria, Australia.
BackgroundA wide range of virtual reality (VR) applications are currently used in rehabilitation to support people with multiple sclerosis (pwMS) in improving limb function, balance, postural control, gait training, and cognitive abilities. Despite its widespread use, there is a lack of systematic evaluation for the effectiveness of VR in the rehabilitation.ObjectiveCommentary on the systematic review by De Keersmaecker et al.
View Article and Find Full Text PDFTher Adv Infect Dis
September 2025
Department of Medicine, Division of Infectious Diseases, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Background: Tumor necrosis factor-alpha (TNF-α) is implicated in the pathogenesis of autoimmune conditions and sepsis. Although anti-TNF-α therapies have demonstrated clinical efficacy in rheumatoid arthritis (RA), there is no established evidence for benefit in patients with sepsis.
Objectives: We sought to quantify circulating TNF-α in patients with RA and compare results to TNF-α levels in sepsis.